Your browser doesn't support javascript.
loading
Bone Penetration of Cycloserine in Osteoarticular Tuberculosis Patients of China.
Zhang, Tingting; Yu, Xia; Wen, Shu'an; Xue, Yi; Xiao, Hua; Ren, Ruyan; Wang, Fen; Dong, Lingling; Qin, Shibing; Huang, Hairong.
Affiliation
  • Zhang T; National Clinical Laboratory on Tuberculosis, Beijing Key Laboratory for Drug-Resistant Tuberculosis Research, Beijing Chest Hospitalgrid.414341.7, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing, China.
  • Yu X; National Clinical Laboratory on Tuberculosis, Beijing Key Laboratory for Drug-Resistant Tuberculosis Research, Beijing Chest Hospitalgrid.414341.7, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing, China.
  • Wen S; National Clinical Laboratory on Tuberculosis, Beijing Key Laboratory for Drug-Resistant Tuberculosis Research, Beijing Chest Hospitalgrid.414341.7, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing, China.
  • Xue Y; National Clinical Laboratory on Tuberculosis, Beijing Key Laboratory for Drug-Resistant Tuberculosis Research, Beijing Chest Hospitalgrid.414341.7, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing, China.
  • Xiao H; National Clinical Laboratory on Tuberculosis, Beijing Key Laboratory for Drug-Resistant Tuberculosis Research, Beijing Chest Hospitalgrid.414341.7, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing, China.
  • Ren R; National Clinical Laboratory on Tuberculosis, Beijing Key Laboratory for Drug-Resistant Tuberculosis Research, Beijing Chest Hospitalgrid.414341.7, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing, China.
  • Wang F; National Clinical Laboratory on Tuberculosis, Beijing Key Laboratory for Drug-Resistant Tuberculosis Research, Beijing Chest Hospitalgrid.414341.7, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing, China.
  • Dong L; National Clinical Laboratory on Tuberculosis, Beijing Key Laboratory for Drug-Resistant Tuberculosis Research, Beijing Chest Hospitalgrid.414341.7, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing, China.
  • Qin S; Department of Orthopedics, Beijing Chest Hospitalgrid.414341.7, Capital Medical University, Beijing, China.
  • Huang H; National Clinical Laboratory on Tuberculosis, Beijing Key Laboratory for Drug-Resistant Tuberculosis Research, Beijing Chest Hospitalgrid.414341.7, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing, China.
Antimicrob Agents Chemother ; 66(5): e0222421, 2022 05 17.
Article in En | MEDLINE | ID: mdl-35400177
ABSTRACT
The cycloserine concentrations in plasma and bone that were collected during operations on 28 osteoarticular tuberculosis (TB) patients treated daily with a 500-mg cycloserine-containing regimen were determined. The median concentrations in plasma and bone were 16.29 µg/mL (interquartile range [IQR], 6.47 µg/mL) and 24.33 µg/g (IQR, 14.68 µg/g), respectively. The median bone/plasma penetration ratio was 0.76 (range, 0.33 to 1.98). Cycloserine could effectively penetrate bone and acquire concentrations comparable to those in plasma, which favors its usage in osteoarticular TB treatment.
Subject(s)
Key words
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tuberculosis, Osteoarticular / Tuberculosis, Multidrug-Resistant Limits: Humans Country/Region as subject: Asia Language: En Journal: Antimicrob Agents Chemother Year: 2022 Document type: Article Affiliation country: China
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tuberculosis, Osteoarticular / Tuberculosis, Multidrug-Resistant Limits: Humans Country/Region as subject: Asia Language: En Journal: Antimicrob Agents Chemother Year: 2022 Document type: Article Affiliation country: China