Topical application of oxygen nano-bubble water enhances the healing process of ischaemic skin wound healing in an animal model.
Int Wound J
; 19(7): 1843-1852, 2022 Nov.
Article
in En
| MEDLINE
| ID: mdl-35403362
ABSTRACT
We investigated the usefulness of oxygen nano-bubble water as an oxygen-rich liquid for wound healing, by analysing its effect on the wound-healing process in rats. Sprague-Dawley rats (n = 36) were divided into two groups the wound-healing model group without ischaemia (n = 18) and the ischaemic group (n = 18). In each rat, an 8 mm diameter full-thickness skin defect wound was created on the back; in rats in the ischaemic group, a bi-pedicle flap (width, 3.6 cm; length, 8.6 cm) was also created. The wounds of six rats from each group were then treated with AQUACELL soaked with oxygen nano-bubble water, and compared with those of control rats, which were treated with purified water (same as that used to make the oxygen nano-bubble water; n = 6) or physiological saline solution (n = 6). There was no significant difference in epithelialisation rate and number of days of epithelialisation among the subgroups in the wound-healing model group. In the ischaemic group, there was a significant improvement in the wound-healing rate and time of the oxygen nano-bubble water subgroup. Oxygen nano-bubble water therapy enhances the ischaemic wound-healing process.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Oxygen
/
Soft Tissue Injuries
Limits:
Animals
Language:
En
Journal:
Int Wound J
Year:
2022
Document type:
Article
Affiliation country:
Japan