Xanthones and anthraquinones from the soil fungus Penicillium sp. DWS10-P-6.
RSC Adv
; 11(5): 3162-3167, 2021 Jan 11.
Article
in En
| MEDLINE
| ID: mdl-35424208
Two new xanthones, oxisterigmatocystins J and K (1-2), and two new anthraquinones, versicolorins D and E (3-4), were isolated from solid cultures of the fungus Penicillium sp. DWS10-P-6, together with twelve known compounds (5-16). Their structures, including their absolute configurations, were characterized on the basis of extensive 1D NMR, 2D NMR, MS and CD spectral data. The cytotoxic activities of compounds 1-12 against HL-60, MDA-MB-231 and PC-3 cells were also evaluated. Compounds 4 and 5 showed significant cytotoxic activity against the HL-60 cell line with IC50 values of 1.65 µM and 1.05 µM, respectively.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
RSC Adv
Year:
2021
Document type:
Article
Country of publication:
United kingdom