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Predictive urinary RNA biomarkers of kidney injury after extracorporeal shock wave lithotripsy.
Tawfick, Ahmed; Matboli, Marwa; Shamloul, Sara; Agwa, Sara H A; Saad, Maha; Shaker, Hassan; Selim, Mohamed M Yassin; Salim, Mohamed S; Radwan, A; Shorbagy, A A; Mousa, Waleed.
Affiliation
  • Tawfick A; Urology Department, Faculty of Medicine, Ain Shams University, Cairo, 11381, Egypt.
  • Matboli M; Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Ain Shams University, Cairo, 11381, Egypt. DrMarwa__Matboly@med.asu.eg.
  • Shamloul S; Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Ain Shams University, Cairo, 11381, Egypt.
  • Agwa SHA; Clinical Pathology and Molecular Genomics Unit, Medical Ain Shams Research Institute, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
  • Saad M; Medical Biochemistry and Molecular Biology Department, Modern University for Technology and Information, Cairo, Egypt.
  • Shaker H; Urology Department, Faculty of Medicine, Ain Shams University, Cairo, 11381, Egypt.
  • Selim MMY; Urology Department, Faculty of Medicine, Ain Shams University, Cairo, 11381, Egypt.
  • Salim MS; Urology Department, Faculty of Medicine, Ain Shams University, Cairo, 11381, Egypt.
  • Radwan A; Urology Department, Faculty of Medicine, Ain Shams University, Cairo, 11381, Egypt.
  • Shorbagy AA; Urology Department, Faculty of Medicine, Ain Shams University, Cairo, 11381, Egypt.
  • Mousa W; Urology Department, Faculty of Medicine, Ain Shams University, Cairo, 11381, Egypt. waleedmousa@med.asu.edu.eg.
World J Urol ; 40(6): 1561-1567, 2022 Jun.
Article in En | MEDLINE | ID: mdl-35428927
BACKGROUND: Extracorporeal shock wave lithotripsy (ESWL) is considered one of the best choices for the treatment of various kinds of urinary tract calculi, although it might cause acute kidney injury. OBJECTIVE: To measure the urinary long non-coding RNA-messenger RNA (LncRNA-mRNA) panel before and after ESWL to evaluate post-ESWL renal injury in a reliable and non-invasive method. PATIENTS AND METHODS: The study included 60 patients with renal stones treated with ESWL and 30 healthy volunteers. Voided urine samples were obtained before, 2 h, and 1 day after ESWL. We measured the urinary level of LncRNA (SBF2-AS1, FENDRR-19) and mRNA (GBP1, NLRP3) by real-time qPCR and compared the results with serum creatinine and eGFR. RESULTS: LncRNA (SBF2-AS1, FENDRR-19) and mRNA (GBP1, NLRP3) levels were higher in patients with renal stones when compared with healthy volunteers. They showed a statistically significant increase in the level of LncRNA-mRNA panel in baseline and after ESWL treatment. CONCLUSION: LncRNA (SBF2-AS1, FENDRR-19) and mRNA (GBP1, NLRP3) levels were significantly elevated following ESWL treatment, highlighting the usefulness of urinary biomarkers in identifying patients at higher risk of developing renal injury after ESWL treatment.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Lithotripsy / Kidney Calculi / RNA, Long Noncoding Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: World J Urol Year: 2022 Document type: Article Affiliation country: Egypt Country of publication: Germany
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Lithotripsy / Kidney Calculi / RNA, Long Noncoding Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: World J Urol Year: 2022 Document type: Article Affiliation country: Egypt Country of publication: Germany