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Discordant Antibody and T-Cell Responses to the Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant in Coronavirus Disease 2019 Messenger RNA Vaccine Recipients.
Woldemeskel, Bezawit A; Garliss, Caroline C; Aytenfisu, Tihitina Y; Johnston, Trevor S; Cox, Andrea L; Karaba, Andrew H; Blankson, Joel N.
Affiliation
  • Woldemeskel BA; Department of Medicine, Johns Hopkins Medicine, Baltimore, Maryland, USA.
  • Garliss CC; Department of Medicine, Johns Hopkins Medicine, Baltimore, Maryland, USA.
  • Aytenfisu TY; Department of Medicine, Johns Hopkins Medicine, Baltimore, Maryland, USA.
  • Johnston TS; Department of Medicine, Johns Hopkins Medicine, Baltimore, Maryland, USA.
  • Cox AL; Department of Medicine, Johns Hopkins Medicine, Baltimore, Maryland, USA.
  • Karaba AH; Department of Medicine, Johns Hopkins Medicine, Baltimore, Maryland, USA.
  • Blankson JN; Department of Medicine, Johns Hopkins Medicine, Baltimore, Maryland, USA.
Clin Infect Dis ; 75(9): 1652-1654, 2022 10 29.
Article in En | MEDLINE | ID: mdl-35438751
ABSTRACT
We compared antibody and T-cell responses against the severe acute respiratory syndrome coronavirus 2 vaccine strain spike protein to responses against the Omicron variant in 15 messenger RNA vaccine recipients. While these individuals had significantly lower levels of antibodies that inhibited Omicron spike protein binding to ACE2, there was no difference in T-cell responses.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: COVID-19 Vaccines / COVID-19 Limits: Humans Language: En Journal: Clin Infect Dis Journal subject: DOENCAS TRANSMISSIVEIS Year: 2022 Document type: Article Affiliation country: United States
Fulltext
Add to My VHL
Print
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: COVID-19 Vaccines / COVID-19 Limits: Humans Language: En Journal: Clin Infect Dis Journal subject: DOENCAS TRANSMISSIVEIS Year: 2022 Document type: Article Affiliation country: United States