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CO2 signaling mediates neurovascular coupling in the cerebral cortex.
Hosford, Patrick S; Wells, Jack A; Nizari, Shereen; Christie, Isabel N; Theparambil, Shefeeq M; Castro, Pablo A; Hadjihambi, Anna; Barros, L Felipe; Ruminot, Iván; Lythgoe, Mark F; Gourine, Alexander V.
Affiliation
  • Hosford PS; Centre for Cardiovascular and Metabolic Neuroscience, Neuroscience, Physiology and Pharmacology, University College London, London, UK. p.hosford@ucl.ac.uk.
  • Wells JA; UCL Centre for Advanced Biomedical Imaging, Division of Medicine, University College London, London, UK.
  • Nizari S; Centre for Cardiovascular and Metabolic Neuroscience, Neuroscience, Physiology and Pharmacology, University College London, London, UK.
  • Christie IN; Centre for Cardiovascular and Metabolic Neuroscience, Neuroscience, Physiology and Pharmacology, University College London, London, UK.
  • Theparambil SM; Centre for Cardiovascular and Metabolic Neuroscience, Neuroscience, Physiology and Pharmacology, University College London, London, UK.
  • Castro PA; Centro de Estudios Científicos (CECs) & Universidad San Sebastián, Valdivia, Chile.
  • Hadjihambi A; Universidad Austral de Chile, Valdivia, Chile.
  • Barros LF; Centre for Cardiovascular and Metabolic Neuroscience, Neuroscience, Physiology and Pharmacology, University College London, London, UK.
  • Ruminot I; Centro de Estudios Científicos (CECs) & Universidad San Sebastián, Valdivia, Chile.
  • Lythgoe MF; Centro de Estudios Científicos (CECs) & Universidad San Sebastián, Valdivia, Chile. iruminot@cecs.cl.
  • Gourine AV; UCL Centre for Advanced Biomedical Imaging, Division of Medicine, University College London, London, UK.
Nat Commun ; 13(1): 2125, 2022 04 19.
Article in En | MEDLINE | ID: mdl-35440557
Neurovascular coupling is a fundamental brain mechanism that regulates local cerebral blood flow (CBF) in response to changes in neuronal activity. Functional imaging techniques are commonly used to record these changes in CBF as a proxy of neuronal activity to study the human brain. However, the mechanisms of neurovascular coupling remain incompletely understood. Here we show in experimental animal models (laboratory rats and mice) that the neuronal activity-dependent increases in local CBF in the somatosensory cortex are prevented by saturation of the CO2-sensitive vasodilatory brain mechanism with surplus of exogenous CO2 or disruption of brain CO2/HCO3- transport by genetic knockdown of electrogenic sodium-bicarbonate cotransporter 1 (NBCe1) expression in astrocytes. A systematic review of the literature data shows that CO2 and increased neuronal activity recruit the same vasodilatory signaling pathways. These results and analysis suggest that CO2 mediates signaling between neurons and the cerebral vasculature to regulate brain blood flow in accord with changes in the neuronal activity.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Neurovascular Coupling Type of study: Systematic_reviews Limits: Animals Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2022 Document type: Article Country of publication: United kingdom

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Neurovascular Coupling Type of study: Systematic_reviews Limits: Animals Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2022 Document type: Article Country of publication: United kingdom