Neuroprotective Properties of Minocycline Against Methylphenidate-Induced Neurodegeneration: Possible Role of CREB/BDNF and Akt/GSK3 Signaling Pathways in Rat Hippocampus.

Motaghinejad, Majid; Motevalian, Manijeh

Motaghinejad, Majid; Motevalian, Manijeh.

Affiliation

Motaghinejad M; Razi Drug Research Center, Iran University of Medical Sciences, Tehran, Shahid Hemmat High way, Iran Univ. Med. Sci., P.O. Box 14496-14525, Tehran, Iran. dr.motaghinejad6@gmail.com.
Motevalian M; Razi Drug Research Center, Iran University of Medical Sciences, Tehran, Shahid Hemmat High way, Iran Univ. Med. Sci., P.O. Box 14496-14525, Tehran, Iran. Motevalian.m@iums.ac.ir.

Neurotox Res ; 40(3): 689-713, 2022 Jun.

Article in En | MEDLINE | ID: mdl-35446003

Subject(s)

Minocycline; Neurodegenerative Diseases; Neuroprotective Agents; Animals; Brain-Derived Neurotrophic Factor/metabolism; Cyclic AMP Response Element-Binding Protein/metabolism; Glutathione/metabolism; Glycogen Synthase Kinase 3/metabolism; Hippocampus/metabolism; Male; Methylphenidate/toxicity; Minocycline/therapeutic use; Neurodegenerative Diseases/chemically induced; Neurodegenerative Diseases/drug therapy; Neuroprotective Agents/therapeutic use; Proto-Oncogene Proteins c-akt/metabolism; Rats; Signal Transduction

Key words

Methylphenidate; Minocycline; Neurodegeneration; P-CREB/BDNF and Akt/GSK3 signaling pathways

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Neuroprotective Agents / Neurodegenerative Diseases / Minocycline Limits: Animals Language: En Journal: Neurotox Res Journal subject: NEUROLOGIA Year: 2022 Document type: Article Affiliation country: Iran Country of publication: United States

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