Prevalence of carbapenem resistance and its potential association with antimicrobial use in humans and animals in rural communities in Vietnam.
JAC Antimicrob Resist
; 4(2): dlac038, 2022 Apr.
Article
in En
| MEDLINE
| ID: mdl-35449721
ABSTRACT
Background:
Vietnam and Southeast Asia are hotspots for antimicrobial resistance; however, little is known on the prevalence of carriage of carbapenem resistance in non-hospitalized humans and in animals. Carbapenem-resistant Enterobacteriaceae (CRE), particularly Escherichia coli (CREC) and Klebsiella pneumoniae (CRKP) and also Acinetobacter baumannii (CRAB) are emerging threats worldwide.Methods:
We investigated healthy humans (nâ=â652), chickens (nâ=â237), ducks (nâ=â150) and pigs (nâ=â143) in 400 small-scale farms in the Mekong Delta of Vietnam. Samples (rectal swabs, faecal swabs) were investigated for carriage of CRE/CRAB and were further characterized phenotypically and genotypically.Results:
In the Mekong Delta of Vietnam, the prevalence of CRE isolates in human rectal swabs was 0.6%, including 4 CREC and 1 CRKP. One pig was infected with CREC (prevalence 0.7%). CRAB was isolated from chickens (nâ=â4) (prevalence 2.1%) and one duck (prevalence 0.7%). CRKP was isolated from a human who was also colonized with CREC. The CRKP strain (ST16), from an 80â year-old person with pneumonia under antimicrobial treatment, genetically clustered with clinical strains isolated in a hospital outbreak in southern Vietnam. The prevalence of CRE was higher among humans that had used antimicrobials within 90â days of the sampling date than those had not (4.2% versus 0.2%) (Pâ=â0.005). All CRE/CRAB strains were MDR, although they were susceptible to colistin and neomycin. The carbapenemase genes identified in study strains were bla NDM and bla OXA.Conclusions:
The finding of a CRKP strain clustering with previous hospital outbreak raises concerns about potential transmission of carbapenem-resistant organisms from hospital to community settings or vice-versa.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Type of study:
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Language:
En
Journal:
JAC Antimicrob Resist
Year:
2022
Document type:
Article
Affiliation country:
Vietnam