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In Vitro and In Silico Studies of Human Tyrosyl-DNA Phosphodiesterase 1 (Tdp1) Inhibition by Stereoisomeric Forms of Lipophilic Nucleosides: The Role of Carbohydrate Stereochemistry in Ligand-Enzyme Interactions.
Dyrkheeva, Nadezhda S; Chernyshova, Irina A; Ivanov, Georgy A; Porozov, Yuri B; Zenchenko, Anastasia A; Oslovsky, Vladimir E; Zakharenko, Alexandra L; Nasyrova, Darina I; Likhatskaya, Galina N; Mikhailov, Sergey N; Lavrik, Olga I; Drenichev, Mikhail S.
Affiliation
  • Dyrkheeva NS; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Lavrentiev Ave. 8, 630090 Novosibirsk, Russia.
  • Chernyshova IA; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Lavrentiev Ave. 8, 630090 Novosibirsk, Russia.
  • Ivanov GA; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilova Str. 32, 119991 Moscow, Russia.
  • Porozov YB; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilova Str. 32, 119991 Moscow, Russia.
  • Zenchenko AA; World-Class Research Center "Digital Biodesign and Personalized Healthcare", I.M. Sechenov First Moscow State Medical University, Trubetskaya Str. 8/2, 119991 Moscow, Russia.
  • Oslovsky VE; Department of Computational Biology, Sirius University of Science and Technology, Olympic Ave. 1, 354340 Sochi, Russia.
  • Zakharenko AL; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilova Str. 32, 119991 Moscow, Russia.
  • Nasyrova DI; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilova Str. 32, 119991 Moscow, Russia.
  • Likhatskaya GN; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Lavrentiev Ave. 8, 630090 Novosibirsk, Russia.
  • Mikhailov SN; Department of Physical and Chemical Biology and Biotechnology, Altai State University, Pr. Lenina 61, 656049 Barnaul, Russia.
  • Lavrik OI; Faculty of Chemistry, National Research University Higher School of Economics, Pokrovsky Boulevard 11-10, 101000 Moscow, Russia.
  • Drenichev MS; Laboratory of Bioassays and Mechanism of Action of Biologically Active Compounds, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences, Prospekt 100 Let Vladivostoky 159, 690022 Vladivostok, Russia.
Molecules ; 27(8)2022 Apr 09.
Article in En | MEDLINE | ID: mdl-35458631
ABSTRACT
Inhibition of human DNA repair enzyme tyrosyl-DNA phosphodiesterase 1 (Tdp1) by different chiral lipophilic nucleoside derivatives was studied. New Tdp1 inhibitors were found in the series of the studied compounds with IC50 = 2.7-6.7 µM. It was shown that D-lipophilic nucleoside derivatives manifested higher inhibition activity than their L-analogs, and configuration of the carbohydrate moiety can influence the mechanism of Tdp1 inhibition.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phosphoric Diester Hydrolases / Nucleosides Limits: Humans Language: En Journal: Molecules Journal subject: BIOLOGIA Year: 2022 Document type: Article Affiliation country: RUSSIA
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phosphoric Diester Hydrolases / Nucleosides Limits: Humans Language: En Journal: Molecules Journal subject: BIOLOGIA Year: 2022 Document type: Article Affiliation country: RUSSIA