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A Neuroanatomy of Positive Affect Display - Subcortical Fiber Pathways Relevant for Initiation and Modulation of Smiling and Laughing.
Coenen, Volker A; Sajonz, Bastian E A; Hurwitz, Trevor A; Böck, Marlies; Hosp, Jonas A; Reinacher, Peter C; Urbach, Horst; Blazhenets, Ganna; Meyer, Philipp T; Reisert, Marco.
Affiliation
  • Coenen VA; Department of Stereotactic and Functional Neurosurgery, Faculty of Medicine, University Medical Center Freiburg, University of Freiburg, Freiburg, Germany.
  • Sajonz BEA; Center for Deep Brain Stimulation, University of Freiburg, Freiburg, Germany.
  • Hurwitz TA; Department of Stereotactic and Functional Neurosurgery, Faculty of Medicine, University Medical Center Freiburg, University of Freiburg, Freiburg, Germany.
  • Böck M; Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada.
  • Hosp JA; Department of Stereotactic and Functional Neurosurgery, Faculty of Medicine, University Medical Center Freiburg, University of Freiburg, Freiburg, Germany.
  • Reinacher PC; Center for Deep Brain Stimulation, University of Freiburg, Freiburg, Germany.
  • Urbach H; Department of Neurology and Clinical Neuroscience, Faculty of Medicine, University Medical Center Freiburg, University of Freiburg, Freiburg, Germany.
  • Blazhenets G; Department of Stereotactic and Functional Neurosurgery, Faculty of Medicine, University Medical Center Freiburg, University of Freiburg, Freiburg, Germany.
  • Meyer PT; Institute for Laser Technology (ILT), Aachen, Germany.
  • Reisert M; Department of Neuroradiology, Medical Faculty, University Medical Center Freiburg, University of Freiburg, Freiburg, Germany.
Front Behav Neurosci ; 16: 817554, 2022.
Article in En | MEDLINE | ID: mdl-35464145
ABSTRACT

Background:

We here report two cases of stimulation induced pathological laughter (PL) under thalamic deep brain stimulation (DBS) for essential tremor and interpret the effects based on a modified neuroanatomy of positive affect display (PAD). Objective/

Hypothesis:

The hitherto existing neuroanatomy of PAD can be augmented with recently described parts of the motor medial forebrain bundle (motorMFB). We speculate that a co-stimulation of parts of this fiber structure might lead to a non-volitional modulation of PAD resulting in PL.

Methods:

We describe the clinical and individual imaging workup and combine the interpretation with normative diffusion tensor imaging (DTI)-tractography descriptions of motor connections of the ventral tegmental area (VTA) (n = 200 subjects, HCP cohort), [[18F] fluorodeoxyglucose (18FDG)] positron emission tomography (PET), and volume of activated tissue simulations. We integrate these results with literature concerning PAD and the neuroanatomy of smiling and laughing.

Results:

DBS electrodes bilaterally co-localized with the MB-pathway ("limiter pathway"). The FDG PET activation pattern allowed to explain pathological PAD. A conceptual revised neuroanatomy of PAD is described.

Conclusion:

Eliciting pathological PAD through chronic thalamic DBS is a new finding and has previously not been reported. PAD is evolution driven, hard wired to the brain and realized over previously described branches of the motorMFB. A major relay region is the VTA/mammillary body complex. PAD physiologically undergoes conscious modulation mainly via the MB branch of the motorMFB (limiter). This limiter in our cases is bilaterally disturbed through DBS. The here described anatomy adds to a previously described framework of neuroanatomy of laughter and humor.
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Front Behav Neurosci Year: 2022 Document type: Article Affiliation country: Germany

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Front Behav Neurosci Year: 2022 Document type: Article Affiliation country: Germany