Peculiar histological and ultrastructural skeletal muscle alterations in a patient with CMV infection and autoimmune myositis: case evaluation and brief literature review.
Acta Myol
; 41(1): 41-47, 2022 Mar.
Article
in En
| MEDLINE
| ID: mdl-35465344
ABSTRACT
We report the case of a young woman with CMV infection, high level of creatine kinase and myopathy. Electromyography showed a myopathic pattern. Muscle biopsy showed a marked increase of NADH enzymatic activity in the central area of almost all type I fibres, few degenerative and necrotic fibres and scattered mononuclear cell infiltrates. Ultrastructural analysis showed a marked disarrangement of sarcomeric structure and large inclusions of thin filaments in some fibres, while immunohistochemistry evidenced alteration in desmin, actin and αB-crystallin protein signals. PCR for CMV detection on muscle sections was negative. Histological, immunological and ultrastructural evaluations were compatible with a necrotic inflammatory myopathy. The correlations between CMV liver infection and the myopathic pattern are discussed. This case underscores the need to consider CMV infection in the differential diagnosis of myopathy with undetermined aetiology, quickly providing directions for a targeted muscle pharmacological intervention.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Autoimmune Diseases
/
Cytomegalovirus Infections
/
Muscular Diseases
/
Myositis
Type of study:
Diagnostic_studies
Limits:
Female
/
Humans
Language:
En
Journal:
Acta Myol
Journal subject:
CARDIOLOGIA
/
FISIOLOGIA
Year:
2022
Document type:
Article
Affiliation country:
Italy
Publication country:
IT
/
ITALIA
/
ITALY
/
ITÁLIA