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Adoptive tumor infiltrating lymphocytes cell therapy for cervical cancer.
Zhu, Yahui; Zhou, Jing; Zhu, Lijing; Hu, Wenjing; Liu, Baorui; Xie, Li.
Affiliation
  • Zhu Y; The Comprehensive Cancer Centre of Drum Tower Hospital, Medical School of Nanjing University, Clinical Cancer Institute of Nanjing University, Nanjing, Jiangsu, China.
  • Zhou J; The Comprehensive Cancer Centre of Drum Tower Hospital, Medical School of Nanjing University, Clinical Cancer Institute of Nanjing University, Nanjing, Jiangsu, China.
  • Zhu L; The Comprehensive Cancer Centre of Drum Tower Hospital, Medical School of Nanjing University, Clinical Cancer Institute of Nanjing University, Nanjing, Jiangsu, China.
  • Hu W; The Comprehensive Cancer Centre of Drum Tower Hospital, Medical School of Nanjing University, Clinical Cancer Institute of Nanjing University, Nanjing, Jiangsu, China.
  • Liu B; The Comprehensive Cancer Centre of Drum Tower Hospital, Medical School of Nanjing University, Clinical Cancer Institute of Nanjing University, Nanjing, Jiangsu, China.
  • Xie L; The Comprehensive Cancer Centre of Drum Tower Hospital, Medical School of Nanjing University, Clinical Cancer Institute of Nanjing University, Nanjing, Jiangsu, China.
Hum Vaccin Immunother ; 18(5): 2060019, 2022 11 30.
Article in En | MEDLINE | ID: mdl-35468048
ABSTRACT
Cervical cancer is one of the most common malignancies among females. As a virus-related cancer, cervical cancer has attracted a lot of attention to develop virus-targeted immune therapy, including vaccine and adoptive immune cell therapy (ACT). Adoptive tumor infiltrating lymphocytes (TILs) cell therapy has been found to be able to control advanced disease progression in some cervical cancer patients who have received several lines of treatment in a pilot clinical trial. In addition, sustainable therapeutic effect has been identified in some cases. The safety risks of TIL therapy for patients are minimal or at least manageable. In this review, we focused on the versatility of TILs and tried to summarize potential strategies to improve the therapeutic effect of TILs and discuss related perspectives.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Uterine Cervical Neoplasms / Lymphocytes, Tumor-Infiltrating Type of study: Clinical_trials Limits: Female / Humans Language: En Journal: Hum Vaccin Immunother Year: 2022 Document type: Article Affiliation country: China
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Uterine Cervical Neoplasms / Lymphocytes, Tumor-Infiltrating Type of study: Clinical_trials Limits: Female / Humans Language: En Journal: Hum Vaccin Immunother Year: 2022 Document type: Article Affiliation country: China