Copper-catalyzed 1,2-Borylacylation of 1,3-Enynes: synthesis of ß-Alkynyl ketones.
Chem Commun (Camb)
; 58(40): 5968-5971, 2022 May 17.
Article
in En
| MEDLINE
| ID: mdl-35475443
ABSTRACT
A copper catalyzed 1,2-borylacylation of 1,3-enynes with B2pin2 and acid chlorides has been developed. Using readily available 1,3-enynes, B2pin2 and acid chlorides as substrates, a range of highly functionalized α,α-disubstituted ß-alkynyl ketones were readily prepared under mild conditions in moderate to good yields. The borylacylated products can be easily derivatized to give several valuable structures. Notably, treatment of the products with NaBO3·4H2O provided 1,2-allenyl ketones, which is proposed to proceed via a retro-aldol process of the corresponding homopropargyl alcohols.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Copper
/
Ketones
Language:
En
Journal:
Chem Commun (Camb)
Journal subject:
QUIMICA
Year:
2022
Document type:
Article