Pu-erh Tea Restored Circadian Rhythm Disruption by Regulating Tryptophan Metabolism.
J Agric Food Chem
; 70(18): 5610-5623, 2022 May 11.
Article
in En
| MEDLINE
| ID: mdl-35475616
ABSTRACT
Pu-erh tea is a healthy beverage rich in phytochemicals, and its effect on the risk of inducing circadian rhythm disorders (CRD) is unclear. In this study, healthy mice were given water or 0.25% (w/v) Pu-erh tea for 7 weeks, followed by a 40 day disruption of the light/dark cycle. CRD caused dysregulation of neurotransmitter secretion and clock gene oscillations, intestinal inflammation, and disruption of intestinal microbes and metabolites. Pu-erh tea boosted the indole and 5-hydroxytryptamine pathways of tryptophan metabolism via the gut-liver-brain axis. Furthermore, its metabolites (e.g., IAA, Indole, 5-HT) enhanced hepatic glycolipid metabolism and down-regulated intestinal oxidative stress by improving the brain hormone release. Tryptophan metabolites and bile acids also promoted liver lipid metabolism and inhibited intestinal inflammation (MyD88/NF-κB) via the enterohepatic circulation. Collectively, 0.25% (w/v) Pu-erh tea has the potential to prevent CRD by promoting indole and 5-HT pathways of tryptophan metabolism and signaling interactions in the gut-liver-brain axis.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Chronobiology Disorders
/
Gastrointestinal Microbiome
Limits:
Animals
Language:
En
Journal:
J Agric Food Chem
Year:
2022
Document type:
Article
Affiliation country:
China