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Role of ferroptosis in gastrointestinal tumors: From mechanisms to therapies.
Si, Chenli; Zhou, Xiang; Deng, Jie; Ye, Shijie; Kong, Lingming; Zhang, Baofu; Wang, Weiming.
Affiliation
  • Si C; The First Clinical Medical College, Wenzhou Medical University, Wenzhou, China.
  • Zhou X; Department of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
  • Deng J; Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, China.
  • Ye S; The First Clinical Medical College, Wenzhou Medical University, Wenzhou, China.
  • Kong L; The First Clinical Medical College, Wenzhou Medical University, Wenzhou, China.
  • Zhang B; The First Clinical Medical College, Wenzhou Medical University, Wenzhou, China.
  • Wang W; Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Cell Biol Int ; 46(7): 997-1008, 2022 Jul.
Article in En | MEDLINE | ID: mdl-35476364
ABSTRACT
Ferroptosis is an iron-dependent nonapoptotic regulated cell death, which is mainly caused by an abnormal increase in lipid oxygen free radicals and an imbalance in redox homeostasis. Recently, ferroptosis has been shown to have implications in various gastrointestinal cancers, such as gastric carcinoma, hepatocellular carcinoma, and pancreatic cancer. This review summarises the latest research on ferroptosis, its mechanism of action, and its role in the progression of different gastrointestinal tumors to provide more information regarding the prevention and treatment of these tumors.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carcinoma, Hepatocellular / Ferroptosis / Gastrointestinal Neoplasms / Liver Neoplasms Limits: Humans Language: En Journal: Cell Biol Int Year: 2022 Document type: Article Affiliation country: China
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carcinoma, Hepatocellular / Ferroptosis / Gastrointestinal Neoplasms / Liver Neoplasms Limits: Humans Language: En Journal: Cell Biol Int Year: 2022 Document type: Article Affiliation country: China