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ALK Protein Expression Patterns in Squamous Cell Carcinoma of the Oral Cavity.
Chrysovergis, Aristeidis; Papanikolaou, Vasileios; Mastronikolis, Nicholas; Tsiambas, Evangelos; Katsinis, Spyros; Manoli, Arezina; Papouliakos, Sotirios; Ragos, Vasileios; Pantos, Pavlos; Peschos, Dimitrios; Mastronikolis, Stylianos; Fotiades, Panagiotis; Mamoulidis, Panagiotis; Spyropoulou, Despoina; Kyrodimos, Efthymios.
Affiliation
  • Chrysovergis A; First ENT Department, Hippocration Hospital, University of Athens, Athens, Greece.
  • Papanikolaou V; First ENT Department, Hippocration Hospital, University of Athens, Athens, Greece.
  • Mastronikolis N; ENT Department, Medical School, University of Patras, Patras, Greece.
  • Tsiambas E; Department of Pathology, Immunohistochemistry and Molecular Biology Laboratory, 401 General Army Hospital, Athens, Greece; tsiambasecyto@yahoo.gr.
  • Katsinis S; Department of Maxillofacial, Medical School, University of Ioannina, Ioannina, Greece.
  • Manoli A; Department of Otorhinolaryngology, Sotiria Thoracic Diseases General Hospital, Athens, Greece.
  • Papouliakos S; Department of Otorhinolaryngology, Sotiria Thoracic Diseases General Hospital, Athens, Greece.
  • Ragos V; Department of Otolaryngology, Gennimatas General Hospital, Athens, Greece.
  • Pantos P; Department of Maxillofacial, Medical School, University of Ioannina, Ioannina, Greece.
  • Peschos D; First ENT Department, Hippocration Hospital, University of Athens, Athens, Greece.
  • Mastronikolis S; Department of Physiology, Medical School, University of Ioannina, Ioannina, Greece.
  • Fotiades P; Department of Ophthalmology, Medical School, University of Patras, Patras, Greece.
  • Mamoulidis P; Department of Surgery, 424 Army Hospital, Thessaloniki, Greece.
  • Spyropoulou D; First ENT Department, Hippocration Hospital, University of Athens, Athens, Greece.
  • Kyrodimos E; ENT Department, ELPIS General Hospital, Athens, Greece.
In Vivo ; 36(3): 1144-1149, 2022.
Article in En | MEDLINE | ID: mdl-35478149
ABSTRACT

BACKGROUND:

Oral squamous cell carcinoma (OSCC) is characterized by a broad spectrum of genomic imbalances, including gross chromosomal (polysomy/aneuploidy) ones as well as specific gene alterations. Aberrant expression of anaplastic lymphoma kinase (ALK) seems to be a useful molecular marker for discriminating patients based on genetic signatures in a variety of solid malignancies, such as lung carcinoma. Our aim was to analyze ALK protein expression patterns in a series of OSCCs. MATERIALS AND

METHODS:

Fifty (n=50) OSCC tissue sections were analyzed by implementing an ALK-based immunohistochemistry protocol. Digital image analysis was performed for measuring the corresponding protein expression levels.

RESULTS:

ALK overexpression was observed in 14/50 (28%) OSCC tissue sections, whereas the rest 36/50 (72%) demonstrated low expression levels. ALK expression was negatively associated with grade (p=0.027) and stage (p=0.0028) of the examined cases.

CONCLUSION:

Abnormal ALK expression in subsets of patients with OSCC seems to be related to an aggressive phenotype (advanced stage/progressive dedifferentiation). ALK protein overexpression may be used as a significant marker for applying targeted therapeutic regimens.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Mouth Neoplasms / Carcinoma, Squamous Cell Type of study: Guideline Limits: Humans Language: En Journal: In Vivo Journal subject: NEOPLASIAS Year: 2022 Document type: Article Affiliation country: Greece
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Mouth Neoplasms / Carcinoma, Squamous Cell Type of study: Guideline Limits: Humans Language: En Journal: In Vivo Journal subject: NEOPLASIAS Year: 2022 Document type: Article Affiliation country: Greece