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Dolutegravir Resistance in Malawi's National HIV Treatment Program.
van Oosterhout, Joep J; Chipungu, Chifundo; Nkhoma, Lyse; Kanise, Hope; Hosseinipour, Mina C; Sagno, Jean Babtiste; Simon, Katherine; Cox, Carrie; Hoffman, Risa; Steegen, Kim; Matola, Bilaal W; Phiri, Sam; Jahn, Andreas; Nyirenda, Rose; Heller, Tom.
Affiliation
  • van Oosterhout JJ; Partners in Hope, Lilongwe, Malawi.
  • Chipungu C; Division of Infectious Diseases, David Geffen School of Medicine, University of California, Los Angeles, California, USA.
  • Nkhoma L; Partners in Hope, Lilongwe, Malawi.
  • Kanise H; The Lighthouse Trust, Lilongwe, Malawi.
  • Hosseinipour MC; Partners in Hope, Lilongwe, Malawi.
  • Sagno JB; University of North Carolina Project Malawi, Lilongwe, Malawi.
  • Simon K; DREAM, Communion of St. Egidio, Blantyre, Malawi.
  • Cox C; Baylor College of Medicine Children's Foundation-Malawi, Lilongwe, Malawi.
  • Hoffman R; Baylor International Pediatric AIDS Initiative, Houston, Texas, USA.
  • Steegen K; Baylor College of Medicine Children's Foundation-Malawi, Lilongwe, Malawi.
  • Matola BW; Baylor International Pediatric AIDS Initiative, Houston, Texas, USA.
  • Phiri S; Division of Infectious Diseases, David Geffen School of Medicine, University of California, Los Angeles, California, USA.
  • Jahn A; Department of Haematology & Molecular Medicine, National Health Laboratory Service, Johannesburg, South Africa.
  • Nyirenda R; Department of Haematology & Molecular Medicine, University of the Witwatersrand, Johannesburg, South Africa.
  • Heller T; Department of Public Health and Family Medicine, Kamuzu University of Health Sciences, Lilongwe, Malawi.
Open Forum Infect Dis ; 9(5): ofac148, 2022 May.
Article in En | MEDLINE | ID: mdl-35493118
ABSTRACT
Dolutegravir HIV drug resistance (HIVDR) data from Africa remain sparse. We reviewed HIVDR results of Malawians on dolutegravir-based antiretroviral therapy (November 2020-September 2021). Of 6462 eligible clients, 33 samples were submitted to South Africa, 27 were sequenced successfully, and 8 (30%) had dolutegravir HIVDR. Malawi urgently requires adequate HIVDR testing capacity.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Open Forum Infect Dis Year: 2022 Document type: Article Affiliation country: Malawi
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Open Forum Infect Dis Year: 2022 Document type: Article Affiliation country: Malawi