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A highly selective quinolizinium-based fluorescent probe for cysteine detection.
O, Wa-Yi; Chan, Wing-Cheung; Xu, Caifeng; Deng, Jie-Ren; Ko, Ben Chi-Bun; Wong, Man-Kin.
Affiliation
  • O WY; The Hong Kong Polytechnic University, Shenzhen Research Institute Shenzhen P. R. China mankin.wong@polyu.edu.hk.
  • Chan WC; State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University Hung Hom Hong Kong P. R. China mankin.wong@polyu.edu.hk ben.ko@polyu.edu.hk.
  • Xu C; State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University Hung Hom Hong Kong P. R. China mankin.wong@polyu.edu.hk ben.ko@polyu.edu.hk.
  • Deng JR; The Hong Kong Polytechnic University, Shenzhen Research Institute Shenzhen P. R. China mankin.wong@polyu.edu.hk.
  • Ko BC; State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University Hung Hom Hong Kong P. R. China mankin.wong@polyu.edu.hk ben.ko@polyu.edu.hk.
  • Wong MK; State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University Hung Hom Hong Kong P. R. China mankin.wong@polyu.edu.hk ben.ko@polyu.edu.hk.
RSC Adv ; 11(53): 33294-33299, 2021 Oct 08.
Article in En | MEDLINE | ID: mdl-35497514
ABSTRACT
A novel fluorescent quinolizinium-based turn-off probe has been developed for selective detection of cysteine. The probe showed high selectivity and sensitivity towards cysteine over other amino acids including the similarly structured homocysteine and glutathione with a detection limit of 0.18 µM (S/N = 3). It was successfully applied to cysteine detection in living cells with low cytotoxicity and quantitative analysis of spiked mouse serum samples with moderate to good recovery (96-109%).
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Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Diagnostic_studies Language: En Journal: RSC Adv Year: 2021 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Diagnostic_studies Language: En Journal: RSC Adv Year: 2021 Document type: Article