Inferring Morphology of a Neuron from In Vivo LFP Data.

ABSTRACT

We propose a computational pipeline that uses biophysical modeling and sequential neural posterior estimation algorithm to infer the position and morphology of single neurons using multi-electrode in vivo extracellular voltage recordings. In this inverse modeling scheme, we designed a generic biophysical single neuron model with stylized morphology that had adjustable parameters for the dimensions of the soma, basal and apical dendrites, and their location and orientations relative to the multi-electrode probe. Preliminary results indicate that the proposed methodology can infer up to eight neuronal parameters well. We highlight the issues involved in the development of the novel pipeline and areas for further improvement.