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Emergence of Dalbavancin, Vancomycin, and Daptomycin Nonsusceptible Staphylococcus aureus in a Patient Treated With Dalbavancin: Case Report and Isolate Characterization.
Zhang, Rutan; Polenakovik, Hari; Barreras Beltran, Ismael A; Waalkes, Adam; Salipante, Stephen J; Xu, Libin; Werth, Brian J.
Affiliation
  • Zhang R; Department of Medicinal Chemistry, University of Washington School of Pharmacy, Seattle, Washington, USA.
  • Polenakovik H; Veterans Affairs Medical Center, Dayton, Ohio, USA.
  • Barreras Beltran IA; Department of Medicine, Wright State University Boonshoft School of Medicine, Dayton, Ohio, USA.
  • Waalkes A; Department of Pharmacy, University of Washington School of Pharmacy, Seattle, Washington, USA.
  • Salipante SJ; Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA.
  • Xu L; Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA.
  • Werth BJ; Department of Medicinal Chemistry, University of Washington School of Pharmacy, Seattle, Washington, USA.
Clin Infect Dis ; 75(9): 1641-1644, 2022 10 29.
Article in En | MEDLINE | ID: mdl-35510938
ABSTRACT
A patient with end-stage renal disease received 2 doses of dalbavancin for methicillin-resistant Staphylococcus aureus (MRSA) arteriovenous fistula infection and presented 5 weeks later with infective endocarditis secondary to vancomycin, daptomycin, and dalbavancin nonsusceptible MRSA. Resistance was associated with walK and scrA mutations, reduced long-chain lipid content, and reduced membrane fluidity.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Staphylococcal Infections / Daptomycin / Methicillin-Resistant Staphylococcus aureus Limits: Humans Language: En Journal: Clin Infect Dis Journal subject: DOENCAS TRANSMISSIVEIS Year: 2022 Document type: Article Affiliation country: United States
Fulltext
Add to My VHL
Print
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Staphylococcal Infections / Daptomycin / Methicillin-Resistant Staphylococcus aureus Limits: Humans Language: En Journal: Clin Infect Dis Journal subject: DOENCAS TRANSMISSIVEIS Year: 2022 Document type: Article Affiliation country: United States