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Hepatic MDM2 Causes Metabolic Associated Fatty Liver Disease by Blocking Triglyceride-VLDL Secretion via ApoB Degradation.
Lin, Huige; Wang, Lin; Liu, Zhuohao; Long, Kekao; Kong, Mengjie; Ye, Dewei; Chen, Xi; Wang, Kai; Wu, Kelvin Kl; Fan, Mengqi; Song, Erfei; Wang, Cunchuan; Hoo, Ruby Lc; Hui, Xiaoyan; Hallenborg, Philip; Piao, Hailong; Xu, Aimin; Cheng, Kenneth Ky.
Affiliation
  • Lin H; Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong.
  • Wang L; Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong.
  • Liu Z; The State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Pokfulam, Hong Kong.
  • Long K; Department of Medicine, The University of Hong Kong, Pokfulam, Hong Kong.
  • Kong M; The State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Pokfulam, Hong Kong.
  • Ye D; Department of Medicine, The University of Hong Kong, Pokfulam, Hong Kong.
  • Chen X; Department of Neurosurgery, Shenzhen Hospital, Southern Medical University, Shenzhen, 518000, P. R. China.
  • Wang K; Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong.
  • Wu KK; Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong.
  • Fan M; Key Laboratory of Glucolipid Metabolic Diseases of the Ministry of Education, Guangdong Pharmaceutical University, Guangzhou, 510000, P. R. China.
  • Song E; Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong.
  • Wang C; Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong.
  • Hoo RL; Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong.
  • Hui X; Key Laboratory of Glucolipid Metabolic Diseases of the Ministry of Education, Guangdong Pharmaceutical University, Guangzhou, 510000, P. R. China.
  • Hallenborg P; Department of Metabolic and Bariatric Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, 510000, P. R. China.
  • Piao H; Department of Metabolic and Bariatric Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, 510000, P. R. China.
  • Xu A; The State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Pokfulam, Hong Kong.
  • Cheng KK; Department of Pharmacology and Pharmacy, The University of Hong Kong, Pokfulam, Hong Kong.
Adv Sci (Weinh) ; 9(20): e2200742, 2022 07.
Article in En | MEDLINE | ID: mdl-35524581
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Apolipoproteins B / Triglycerides / Proto-Oncogene Proteins c-mdm2 / Fatty Liver / Lipoproteins, VLDL / Liver / Obesity Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Animals / Humans Language: En Journal: Adv Sci (Weinh) Year: 2022 Document type: Article Affiliation country: Hong Kong Country of publication: Germany
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Apolipoproteins B / Triglycerides / Proto-Oncogene Proteins c-mdm2 / Fatty Liver / Lipoproteins, VLDL / Liver / Obesity Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Animals / Humans Language: En Journal: Adv Sci (Weinh) Year: 2022 Document type: Article Affiliation country: Hong Kong Country of publication: Germany