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Waning Immunity Against Respiratory Syncytial Virus During the Coronavirus Disease 2019 Pandemic.
Reicherz, Frederic; Xu, Rui Yang; Abu-Raya, Bahaa; Majdoubi, Abdelilah; Michalski, Christina; Golding, Liam; Stojic, Aleksandra; Vineta, Marina; Granoski, Madison; Cieslak, Zenon; Chacko, Anil; Desai, Neil; Sekirov, Inna; Marchant, David J; Lavoie, Pascal M.
Affiliation
  • Reicherz F; British Columbia Children's Hospital Research Institute, Vancouver, Canada.
  • Xu RY; Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, Canada.
  • Abu-Raya B; British Columbia Children's Hospital Research Institute, Vancouver, Canada.
  • Majdoubi A; Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, Canada.
  • Michalski C; British Columbia Children's Hospital Research Institute, Vancouver, Canada.
  • Golding L; Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, Canada.
  • Stojic A; British Columbia Children's Hospital Research Institute, Vancouver, Canada.
  • Vineta M; Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, Canada.
  • Granoski M; British Columbia Children's Hospital Research Institute, Vancouver, Canada.
  • Cieslak Z; Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, Canada.
  • Chacko A; British Columbia Children's Hospital Research Institute, Vancouver, Canada.
  • Desai N; Reproductive and Developmental Sciences Program, Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, Canada.
  • Sekirov I; Li Ka Shing Institute of Virology, Department of Medical Microbiology and Immunology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.
  • Marchant DJ; British Columbia Children's Hospital Research Institute, Vancouver, Canada.
  • Lavoie PM; Reproductive and Developmental Sciences Program, Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, Canada.
J Infect Dis ; 226(12): 2064-2068, 2022 12 13.
Article in En | MEDLINE | ID: mdl-35524952
Health jurisdictions have seen a near-disappearance of respiratory syncytial virus (RSV) during the first year of the coronavirus disease 2019 (COVID-19) pandemic. Over this corresponding period, we report a reduction in RSV antibody levels and live virus neutralization in sera from women of childbearing age and infants between May to June 2020 and February to June 2021, in British Columbia (BC), Canada. This supports that antibody immunity against RSV is relatively short-lived and that maintaining optimal antibody levels in infants requires repeated maternal viral exposure. Waning immunity may explain the interseasonal resurgence of RSV cases observed in BC and other countries.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Respiratory Syncytial Virus, Human / Respiratory Syncytial Virus Infections / Respiratory Syncytial Virus Vaccines / COVID-19 Limits: Female / Humans / Infant Country/Region as subject: America do norte Language: En Journal: J Infect Dis Year: 2022 Document type: Article Affiliation country: Canada Country of publication: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Respiratory Syncytial Virus, Human / Respiratory Syncytial Virus Infections / Respiratory Syncytial Virus Vaccines / COVID-19 Limits: Female / Humans / Infant Country/Region as subject: America do norte Language: En Journal: J Infect Dis Year: 2022 Document type: Article Affiliation country: Canada Country of publication: United States