A rational design of copper-selenium nanoclusters that cures sepsis by consuming endogenous H2S to trigger photothermal therapy and ROS burst.
Biomater Sci
; 10(12): 3137-3157, 2022 Jun 14.
Article
in En
| MEDLINE
| ID: mdl-35546338
The treatment of sepsis caused by bacterial infections is still a huge clinical challenge. As sepsis causes high levels of endogenous H2S in vivo, researchers can design nanomedicines to treat sepsis by in situ sulfurization. Here, we designed and synthesized Cu2O-coated non-metallic core-shell selenium nanoparticles. To cure mice sepsis by ROS burst. Our experimental data displayed that the photothermal effect of Se@Cu9S8 produced by the reaction of Se@Cu2O and endogenous H2S is synergistically antibacterial, and Se@Cu2O has the characteristics of low side effects and high biocompatibility. In summary, our research results verified our design, that copper-selenium nanoclusters may be an efficient strategy to cure sepsis by in situ sulfurization of endogenous H2S, triggering ROS eruptions and photothermal therapy.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Selenium
/
Sepsis
/
Nanoparticles
Limits:
Animals
Language:
En
Journal:
Biomater Sci
Year:
2022
Document type:
Article
Affiliation country:
China
Country of publication:
United kingdom