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Imbalance in Sirt1 Alternative Splicing in Response to Chronic Stress during the Adolescence Period in Female Mice.
Shlomi, Shir; Toledano, Roni; Nitzan, Keren; Shahaf, Sigal Dror; Break, Emanuela P; Frenkel, Dan; Doron, Ravid.
Affiliation
  • Shlomi S; Department of Neurobiology, The George S. Wise Faculty of Life Sciences, School of Neurobiology, Biochemistry and Biophysics, Tel Aviv University, Tel Aviv 6997801, Israel.
  • Toledano R; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv 6997801, Israel.
  • Nitzan K; Department of Education and Psychology, The Open University, Raanana 43107, Israel.
  • Shahaf SD; Department of Education and Psychology, The Open University, Raanana 43107, Israel.
  • Break EP; Department of Neurobiology, The George S. Wise Faculty of Life Sciences, School of Neurobiology, Biochemistry and Biophysics, Tel Aviv University, Tel Aviv 6997801, Israel.
  • Frenkel D; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv 6997801, Israel.
  • Doron R; Department of Education and Psychology, The Open University, Raanana 43107, Israel.
Int J Mol Sci ; 23(9)2022 Apr 29.
Article in En | MEDLINE | ID: mdl-35563336
Stressful unpredictable life events have been implicated in numerous diseases. It is now becoming clear that some life periods are more vulnerable than others. As adolescence is a sensitive period in brain development, the long-term effects of stress during this period could be significant. We investigated the long-term effects of exposure to unpredictable chronic mild stress in adolescent mice on alternative splicing of Sirtuin 1. One-month-old mice were exposed to 4 weeks of UCMS and examined for anxiety and cognition at the age of 2, 4 and 6 months. We found a rise in anxious behavior immediately after the exposure to stress. Notably, there was a long-term impairment of performance in cognitive tasks and an imbalance in Sirtuin 1 and TrkB receptor alternative splicing in the stress-exposed mice compared with controls. To conclude, our results show that exposure to unpredictable chronic mild stress during adolescence affects cognition in adulthood. Understanding pathways affiliated with stress may help minimize the long-term emotional effects of an unpredictable, stressful event.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stress, Psychological / Alternative Splicing / Sirtuin 1 Limits: Animals Language: En Journal: Int J Mol Sci Year: 2022 Document type: Article Affiliation country: Israel Country of publication: Switzerland

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stress, Psychological / Alternative Splicing / Sirtuin 1 Limits: Animals Language: En Journal: Int J Mol Sci Year: 2022 Document type: Article Affiliation country: Israel Country of publication: Switzerland