The role of platelet glycoprotein IIbâ/âIIIa inhibitors in current treatment of acute coronary syndrome.
Kardiologiia
; 62(4): 64-72, 2022 Apr 30.
Article
in En
| MEDLINE
| ID: mdl-35569165
ABSTRACT
Current management of patients with acute coronary syndrome (ACS) includes a dual antiplatelet therapy with acetylsalicylic acid and a platelet P2Y12 receptor inhibitor. For patients without a high risk of bleeding, prasugrel and ticagrelor are preferred, since their effect is more pronounced, less dependent on metabolism of a specific patient, and occurs faster that the effect of clopidogrel. The prescription rate of platelet glycoprotein IIb/IIIa (GP IIbâ/âIIIa) receptor inhibitors has considerably decreased. However, these drugs remain relevant in percutaneous coronary interventions in patients with a high risk of coronary thrombosis or a massive coronary thrombus, in thrombotic complications of the procedure, and in the "no-reflow" phenomenon. The intravenous route of GP IIbâ/âIIIa inhibitor administration provides their effectiveness in patients with difficulties of drug intake or with impaired absorption of oral medications. This review presents clinical and pharmacological characteristics of various GP IIbâ/âIIIa inhibitors and data of randomized clinical studies and registries of recent years that evaluated results of their use in patients with ACS.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Acute Coronary Syndrome
Type of study:
Clinical_trials
Limits:
Humans
Language:
En
Journal:
Kardiologiia
Year:
2022
Document type:
Article