Are platelet indices promising ratios for predicting pediatric septic shock prognosis?
Bratisl Lek Listy
; 123(6): 444-448, 2022.
Article
in En
| MEDLINE
| ID: mdl-35576547
ABSTRACT
OBJECTIVES:
The aim of the present study was to determine the prognostic value of thrombocytopenia, platelet indices (MPV/PLT and PDW/PLT) in children with septic shock.BACKGROUND:
Septic shock is one of the major causes of mortality among children worldwide.METHODS:
A retrospective analysis was made of children admitted to the pediatric intensive care unit between November 2010 and December 2019. Two hundred four children were included; they were diagnosed with septic shock according to the international pediatric sepsis consensus conference criteria. The MPV/platelet ratio and PDW/platelet ratios were estimated as the MPV and PDW values divided by the platelet count on the first three days of hospitalization. The clinical outcome was 28-day mortality.RESULTS:
MPV/PLT and PDW/PLT ratios were found to be significantly higher in the non-survivors than survivor (p≤0.001). In the multivariate logistic regression analysis, higher MPV/platelet ratios at 72h (OR 7.41; 95% CI 1.25-43.7; p=0.027) and PDW/platelet ratios at 72h (OR 2.9; 95% CI 1.13-7.50; p=0.027) were significant risk factors for mortality.CONCLUSIONS:
Platelet indices are useful laboratory parameters in septic shock. MPV/PLT and PDW/PLT ratios can be promising reliable markers for 28-day mortality in children with septic shock (Tab. 4, Fig. 1, Ref. 29).Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Shock, Septic
Type of study:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Child
/
Humans
Language:
En
Journal:
Bratisl Lek Listy
Year:
2022
Document type:
Article