Molecular basis of base substitution hotspots in Escherichia coli.
Nature
; 274(5673): 775-80, 1978 Aug 24.
Article
in En
| MEDLINE
| ID: mdl-355893
ABSTRACT
In the lacI gene of Escherichia coli spontaneous base substituion hotspots occur at 5-methylcytosine residues. The hotspots disappear when the respective cytosines are not methylated. We suggest that the hotspots may result from the spontaneous deamination of 5-methylcytosine to thymine, which is not excised by the enzyme DNA-uracil glycosidase.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Escherichia coli
/
Genes
/
Lactose
/
Mutation
Language:
En
Journal:
Nature
Year:
1978
Document type:
Article