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Assessing the role of low volume disease in endometrial cancer.
Bogani, Giorgio; Palaia, Innocenza; Perniola, Giorgia; Fracassi, Alice; Cuccu, Ilaria; Golia D'Auge, Tullio; Casorelli, Assunta; Santangelo, Giusi; Fischetti, Margherita; Muzii, Ludovico; Benedetti Panici, Pierluigi; Di Donato, Violante.
Affiliation
  • Bogani G; Department of Maternal and Child Health and Urological Sciences, Sapienza University, Policlinico Umberto I, Rome, Italy. Electronic address: giorgiobogani@yahoo.it.
  • Palaia I; Department of Maternal and Child Health and Urological Sciences, Sapienza University, Policlinico Umberto I, Rome, Italy.
  • Perniola G; Department of Maternal and Child Health and Urological Sciences, Sapienza University, Policlinico Umberto I, Rome, Italy.
  • Fracassi A; Department of Maternal and Child Health and Urological Sciences, Sapienza University, Policlinico Umberto I, Rome, Italy.
  • Cuccu I; Department of Maternal and Child Health and Urological Sciences, Sapienza University, Policlinico Umberto I, Rome, Italy.
  • Golia D'Auge T; Department of Maternal and Child Health and Urological Sciences, Sapienza University, Policlinico Umberto I, Rome, Italy.
  • Casorelli A; Department of Maternal and Child Health and Urological Sciences, Sapienza University, Policlinico Umberto I, Rome, Italy.
  • Santangelo G; Department of Maternal and Child Health and Urological Sciences, Sapienza University, Policlinico Umberto I, Rome, Italy.
  • Fischetti M; Department of Maternal and Child Health and Urological Sciences, Sapienza University, Policlinico Umberto I, Rome, Italy.
  • Muzii L; Department of Maternal and Child Health and Urological Sciences, Sapienza University, Policlinico Umberto I, Rome, Italy.
  • Benedetti Panici P; Department of Maternal and Child Health and Urological Sciences, Sapienza University, Policlinico Umberto I, Rome, Italy.
  • Di Donato V; Department of Maternal and Child Health and Urological Sciences, Sapienza University, Policlinico Umberto I, Rome, Italy.
Eur J Obstet Gynecol Reprod Biol ; 274: 68-72, 2022 Jul.
Article in En | MEDLINE | ID: mdl-35598492
ABSTRACT
The role of retroperitoneal staging in endometrial cancer is still unclear. Although the prognostic value of lymphadenectomy has been demonstrated no data support the therapeutic value of nodal dissection. Sentinel node mapping represents an evolution of lymphadenectomy. Sentinel node mapping allows a more accurate identification of low-volume diseases (i.e., micrometastasis and isolated tumor cells) that are not always detectable via conventional histopathological evaluation. Adjuvant therapy might play a role in patients with low-volume disease. However, the presence of isolated tumor cells alone seems to not impact outcomes of endometrioid endometrial cancer patients. Hence, the choice to deliver adjuvant therapies has to be tailored based on uterine factors only. The introduction of molecular and genomic profiling would be useful in selecting appropriate surgical and adjuvant treatments. The molecular-integrated risk profile should be integrated in clinical practice to overcome the need of retroperitoneal staging (in case of non-bulky nodes) in patients at low risk.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Endometrial Neoplasms / Sentinel Lymph Node Type of study: Prognostic_studies Limits: Female / Humans Language: En Journal: Eur J Obstet Gynecol Reprod Biol Year: 2022 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Endometrial Neoplasms / Sentinel Lymph Node Type of study: Prognostic_studies Limits: Female / Humans Language: En Journal: Eur J Obstet Gynecol Reprod Biol Year: 2022 Document type: Article