Papillitis and uveitis complicating Bacillus Calmette-Guérin immunotherapy.
BMJ Case Rep
; 15(5)2022 May 23.
Article
in En
| MEDLINE
| ID: mdl-35606040
ABSTRACT
Intravesical Bacillus Calmette-Guérin (BCG) administration was used to treat bladder carcinoma in a woman in her 60s. Severe bilateral non-granulomatous anterior uveitis and gross papillitis developed subsequently. The severe BCG-induced bilateral uveitis and papillitis were treated with high dose oral corticosteroids, with topical steroids and cycloplegics. Resolution of her ocular symptoms and signs eventuated. On lumbar puncture, no evidence of systemic spread of the BCG was found. Visual acuity returned to 6/9 in each eye with subsequent resolution of papillitis. Repeat cystoscopy demonstrated no evidence of recurrent bladder tumour.Hypersensitivity reactions are well recognised with Tubercle bacilli While both hypersensitivity reactions and dissemination of BCG throughout the body have been previously documented, the literature demonstrates that this case is the first example in which papillitis and bilateral uveitis were the prominent ophthalmological features.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Urinary Bladder Neoplasms
/
BCG Vaccine
/
Papilledema
/
Uveitis, Anterior
/
Immunotherapy
Limits:
Female
/
Humans
Language:
En
Journal:
BMJ Case Rep
Year:
2022
Document type:
Article
Affiliation country:
Australia