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Improved trends in survival and engraftment after single cord blood transplantation for adult acute myeloid leukemia.
Konuma, Takaaki; Mizuno, Shohei; Kondo, Tadakazu; Arai, Yasuyuki; Uchida, Naoyuki; Takahashi, Satoshi; Tanaka, Masatsugu; Kuriyama, Takuro; Miyakoshi, Shigesaburo; Onizuka, Makoto; Ota, Shuichi; Sugio, Yasuhiro; Kouzai, Yasushi; Kawakita, Toshiro; Kobayashi, Hikaru; Ozawa, Yukiyasu; Kimura, Takafumi; Ichinohe, Tatsuo; Atsuta, Yoshiko; Yanada, Masamitsu.
Affiliation
  • Konuma T; Department of Hematology/Oncology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan. tkonuma@ims.u-tokyo.ac.jp.
  • Mizuno S; Division of Hematology, Department of Internal Medicine, Aichi Medical University, Nagakute, Japan.
  • Kondo T; Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Arai Y; Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Uchida N; Department of Hematology, Toranomon Hospital, Tokyo, Japan.
  • Takahashi S; Division of Clinical Precision Research Platform, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
  • Tanaka M; Department of Hematology, Kanagawa Cancer Center, Yokohama, Japan.
  • Kuriyama T; Department of Hematology, Hamanomachi Hospital, Fukuoka, Japan.
  • Miyakoshi S; Department of Hematology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan.
  • Onizuka M; Department of Hematology and Oncology, Tokai University School of Medicine, Isehara, Japan.
  • Ota S; Department of Hematology, Sapporo Hokuyu Hospital, Sapporo, Japan.
  • Sugio Y; Department of Internal Medicine, Kitakyushu City Hospital Organization, Kitakyushu Municipal Medical Center, Kitakyushu, Japan.
  • Kouzai Y; Department of Transfusion Medicine, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan.
  • Kawakita T; Department of Hematology, National Hospital Organisation Kumamoto Medical Center, Kumamoto, Japan.
  • Kobayashi H; Department of Hematology, Nagano Red Cross Hospital, Nagano, Japan.
  • Ozawa Y; Department of Hematology, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan.
  • Kimura T; Preparation Department, Japanese Red Cross Kinki Block Blood Center, Osaka, Japan.
  • Ichinohe T; Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan.
  • Atsuta Y; Japanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan.
  • Yanada M; Department of Registry Science for Transplant and Cellular Therapy, Aichi Medical University School of Medicine, Nagakute, Japan.
Blood Cancer J ; 12(5): 81, 2022 05 25.
Article in En | MEDLINE | ID: mdl-35614057
Unrelated cord blood transplantation (CBT) is an alternative curative option for adult patients with acute myeloid leukemia (AML) who need allogeneic hematopoietic cell transplantation (HCT) but lack an HLA-matched related or unrelated donor. However, large-scale data are lacking on CBT outcomes for unselected adult AML. To investigate the trends of survival and engraftment after CBT over the past 22 years, we retrospectively evaluated the data of patients with AML in Japan according to the time period of CBT (1998-2007 vs 2008-2013 vs 2014-2019). A total of 5504 patients who received single-unit CBT as first allogeneic HCT for AML were included. Overall survival (OS) at 2 years significantly improved over time. The improved OS among patients in ≥ complete remission (CR)3 and active disease at CBT was mainly due to a reduction of relapse-related mortality, whereas among patients in first or second CR at CBT, this was due mainly to a reduction of non-relapse mortality. The trends of neutrophil engraftment also improved over time. This experience demonstrated that the survival and engraftment rate after CBT for this group has improved over the past 22 years.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukemia, Myeloid, Acute / Hematopoietic Stem Cell Transplantation / Cord Blood Stem Cell Transplantation / Graft vs Host Disease Type of study: Observational_studies Limits: Adult / Humans Language: En Journal: Blood Cancer J Year: 2022 Document type: Article Affiliation country: Japan Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukemia, Myeloid, Acute / Hematopoietic Stem Cell Transplantation / Cord Blood Stem Cell Transplantation / Graft vs Host Disease Type of study: Observational_studies Limits: Adult / Humans Language: En Journal: Blood Cancer J Year: 2022 Document type: Article Affiliation country: Japan Country of publication: United States