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Development of novel conformationally restricted selective Clk1/4 inhibitors through creating an intramolecular hydrogen bond involving an imide linker.
El-Gamil, Dalia S; ElHady, Ahmed K; Chen, Po-Jen; Hwang, Tsong-Long; Abadi, Ashraf H; Abdel-Halim, Mohammad; Engel, Matthias.
Affiliation
  • El-Gamil DS; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, 11835, Egypt; Department of Chemistry, Faculty of Pharmacy, Ahram Canadian University, Cairo, 12451, Egypt. Electronic address: daliashgamil@gmail.com.
  • ElHady AK; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, 11835, Egypt; School of Life and Medical Sciences, University of Hertfordshire Hosted By Global Academic Foundation, New Administrative Capital, Cairo, 11865, Egypt. Electronic address:
  • Chen PJ; Department of Medical Research, E-Da Hospital, Kaohsiung, 824005, Taiwan. Electronic address: ed113510@edah.org.tw.
  • Hwang TL; Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan, 333, Taiwan; Research Center for Chinese Herbal Medicine, Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, 333, Taiwan; De
  • Abadi AH; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, 11835, Egypt. Electronic address: ashraf.abadi@guc.edu.eg.
  • Abdel-Halim M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, 11835, Egypt. Electronic address: mohammad.abdel-halim@guc.edu.eg.
  • Engel M; Pharmaceutical and Medicinal Chemistry, Saarland University, Campus C2.3, D-66123, Saarbrücken, Germany. Electronic address: ma.engel@mx.uni-saarland.de.
Eur J Med Chem ; 238: 114411, 2022 Aug 05.
Article in En | MEDLINE | ID: mdl-35635953
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein-Tyrosine Kinases / Protein Kinase Inhibitors Language: En Journal: Eur J Med Chem Year: 2022 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein-Tyrosine Kinases / Protein Kinase Inhibitors Language: En Journal: Eur J Med Chem Year: 2022 Document type: Article