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Sexual function and depressive symptoms in men with hypoprolactinaemia secondary to overtreatment of prolactin excess: A pilot study.
Krysiak, Robert; Kowalcze, Karolina; Okopien, Boguslaw.
Affiliation
  • Krysiak R; Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland. Electronic address: r.krysiak@interia.pl.
  • Kowalcze K; Department of Paediatrics in Bytom, School of Health Sciences in Katowice, Medical University of Silesia, Katowice, Poland.
  • Okopien B; Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland.
Endocrinol Diabetes Nutr (Engl Ed) ; 69(4): 279-288, 2022 Apr.
Article in En | MEDLINE | ID: mdl-35636912
BACKGROUND: Low prolactin levels have been found to impair libido and arousal, as well as to reduce wellbeing in young women. OBJECTIVE: The aim of this study was to investigate whether drug-induced hypoprolactinaemia affects male sexual function and depressive symptoms. METHODS: The study population consisted of three groups of young and middle-aged men. Two groups were treated with dopamine agonists because of previous hyperprolactinaemia but differed in current prolactin levels, which were <3ng/ml (n=12; group 1) or within the reference range (3-20ng/ml) (n=20; group 2). The control group (group 3) included 24 dopamine agonist-naïve normoprolactinaemic men. During the study, doses of dopaminergic agents in group 1 were reduced by 25-50% compared to doses before the start of the study. Circulating levels of prolactin, testosterone, free calculated testosterone, dehydroepiandrosterone-sulphate, oestradiol and gonadotropins were measured upon enrolment in the study and six months later. Moreover, at the beginning and the end of the study, all men enrolled completed questionnaires assessing sexual functioning (IIEF-15) and depressive symptoms (BDI-II). RESULTS: Group 1 differed from groups 2 and 3 in domain scores for sexual desire and erectile function, and in the overall BDI-II score. It was also characterised by lower levels of total testosterone and calculated free testosterone. Reduction of drug doses normalised sexual desire and erectile function, reduced BDI-II scores and increased prolactin as well as total and free calculated testosterone. Groups 2 and 3 did not differ from each other in sexual functioning, depressive symptoms or hormone levels. CONCLUSIONS: The results obtained indicate that men with dopamine agonist-induced hypoprolactinaemia are characterised by impaired sexual functioning and reduced wellbeing. These disturbances are a consequence of subnormal prolactin levels and do not seem to reflect adverse effects of dopamine agonists.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prolactin / Erectile Dysfunction Type of study: Diagnostic_studies Limits: Female / Humans / Male / Middle aged Language: En Journal: Endocrinol Diabetes Nutr (Engl Ed) Year: 2022 Document type: Article Country of publication: Spain

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prolactin / Erectile Dysfunction Type of study: Diagnostic_studies Limits: Female / Humans / Male / Middle aged Language: En Journal: Endocrinol Diabetes Nutr (Engl Ed) Year: 2022 Document type: Article Country of publication: Spain