Epigenetics and Neuroinflammation Associated With Neurodevelopmental Disorders: A Microglial Perspective.
Front Cell Dev Biol
; 10: 852752, 2022.
Article
in En
| MEDLINE
| ID: mdl-35646933
ABSTRACT
Neuroinflammation is a cause of neurodevelopmental disorders such as autism spectrum disorders, fetal alcohol syndrome, and cerebral palsy. Converging lines of evidence from basic and clinical sciences suggest that dysregulation of the epigenetic landscape, including DNA methylation and miRNA expression, is associated with neuroinflammation. Genetic and environmental factors can affect the interaction between epigenetics and neuroinflammation, which may cause neurodevelopmental disorders. In this minireview, we focus on neuroinflammation that might be mediated by epigenetic dysregulation in microglia, and compare studies using mammals and zebrafish.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Type of study:
Risk_factors_studies
Language:
En
Journal:
Front Cell Dev Biol
Year:
2022
Document type:
Article
Affiliation country:
Japan