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Epidemiological characteristics of hand, foot, and mouth disease clusters during 2016-2020 in Beijing, China.
Cui, Yan; Yang, Yan-Na; Zheng, Ran-Ran; Xie, Ming-Zhu; Zhang, Wan-Xue; Chen, Lin-Yi; Du, Juan; Yang, Yang; Xi, Lu; Li, Hua; Li, Hong-Jun; Lu, Qing-Bin.
Affiliation
  • Cui Y; Institute for Infectious Diseases and Endemic Diseases Prevention and Control, Beijing Tongzhou Center for Diseases Prevention and Control, Beijing, China.
  • Yang YN; Institute for Infectious Diseases and Endemic Diseases Prevention and Control, Beijing Tongzhou Center for Diseases Prevention and Control, Beijing, China.
  • Zheng RR; Institute for Infectious Diseases and Endemic Diseases Prevention and Control, Beijing Tongzhou Center for Diseases Prevention and Control, Beijing, China.
  • Xie MZ; Department of Laboratorial Science and Technology & Vaccine Research Center, School of Public Health, Peking University, Beijing, China.
  • Zhang WX; Global Center for Infectious Disease and Policy Research & Global Health and Infectious Diseases Group, Peking University, Beijing, China.
  • Chen LY; Department of Laboratorial Science and Technology & Vaccine Research Center, School of Public Health, Peking University, Beijing, China.
  • Du J; Global Center for Infectious Disease and Policy Research & Global Health and Infectious Diseases Group, Peking University, Beijing, China.
  • Yang Y; Department of Laboratorial Science and Technology & Vaccine Research Center, School of Public Health, Peking University, Beijing, China.
  • Xi L; Global Center for Infectious Disease and Policy Research & Global Health and Infectious Diseases Group, Peking University, Beijing, China.
  • Li H; Department of Laboratorial Science and Technology & Vaccine Research Center, School of Public Health, Peking University, Beijing, China.
  • Li HJ; Global Center for Infectious Disease and Policy Research & Global Health and Infectious Diseases Group, Peking University, Beijing, China.
  • Lu QB; Institute for Infectious Diseases and Endemic Diseases Prevention and Control, Beijing Center for Diseases Prevention and Control, Beijing, China.
J Med Virol ; 94(10): 4934-4943, 2022 10.
Article in En | MEDLINE | ID: mdl-35655366
Hand, foot, and mouth disease (HFMD) is an infectious disease that usually occurs in children under 5 years and is caused by a group of enteroviruses. This study aimed to investigate the epidemiological characteristics of HFMD clusters from 2016 to 2020 in Tongzhou, Beijing, and explored the genetic evolution of CV-A6. The HFMD case information came from the Information System of China Center for Disease Control and Prevention (CDC), as well as the clusters information verification and on-site investigation by Tongzhou CDC. ARIMA model was applied to forecast HFMD clusters in 2020. Totally 440 HFMD clusters were reported during 2016-2020. The large peak of the clusters occurred in April-July, followed by a smaller peak in October-November during 2016-2019. However, in 2020, the two peaks disappeared. The main site of HFMD clusters was childcare facilities (65.0%) and mostly occurred in urban areas (46.1%). The detection rate of CV-A6 was the highest (36.1%), and cases with CV-A6 infection had the highest proportion of fever. The phylogenetic analysis based on CV-A6 VP1 gene showed that the predominant strains mainly located in Group F during 2016-2017, while changed into Group A during 2018-2020. HFMD clusters presented seasonality, mainly located in childcare facilities and urban areas, and CV-A6 was the major causative agent. Targeted prevention and control measures should be taken to reduce HFMD clusters.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Enterovirus / Hand, Foot and Mouth Disease Type of study: Prognostic_studies Limits: Child / Child, preschool / Humans / Infant Country/Region as subject: Asia Language: En Journal: J Med Virol Year: 2022 Document type: Article Affiliation country: China Country of publication: United States

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Enterovirus / Hand, Foot and Mouth Disease Type of study: Prognostic_studies Limits: Child / Child, preschool / Humans / Infant Country/Region as subject: Asia Language: En Journal: J Med Virol Year: 2022 Document type: Article Affiliation country: China Country of publication: United States