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General and Skin-Specific Health-Related Quality of Life in Patients With Atopic Dermatitis Before and During the COVID-19 Pandemic.
Koszorú, Kamilla; Hajdu, Krisztina; Brodszky, Valentin; Szabó, Ákos; Borza, Júlia; Bodai, Katalin; Pónyai, Györgyi; Szegedi, Andrea; Sárdy, Miklós; Rencz, Fanni.
Affiliation
  • Brodszky V; Department of Health Economics, Corvinus University of Budapest, Hungary.
  • Borza J; From the Department of Dermatology, Venereology and Dermatooncology, Semmelweis University.
  • Bodai K; Saint Martin Outpatient Center, Pannonhalma.
  • Pónyai G; From the Department of Dermatology, Venereology and Dermatooncology, Semmelweis University.
  • Rencz F; Department of Health Economics, Corvinus University of Budapest, Hungary.
Dermatitis ; 33(6S): S92-S103, 2022.
Article in En | MEDLINE | ID: mdl-35674639
BACKGROUND: Few studies have investigated health-related quality of life (HRQoL) in patients with atopic dermatitis (AD) during the COVID-19 pandemic. OBJECTIVES: The objectives of this study were to compare HRQoL in adult AD patients before and during the pandemic and to assess measurement performance of 4 HRQoL measures. METHODS: Between 2018 and 2021, a multicenter, cross-sectional survey was conducted, involving 218 adult AD patients. Health-related quality of life outcomes included the EQ-5D-5L, Skindex-16, Dermatology Life Quality Index (DLQI), and DLQI-Relevant (DLQI-R). Severity was measured using objective SCORing Atopic Dermatitis, Eczema Area and Severity Index, and Investigator Global Assessment. RESULTS: The mean ± SD EQ-5D-5L utility, Skindex-16, DLQI, and DLQI-R scores were 0.82 ± 0.22, 56.84 ± 27.46, 13.44 ± 8.46, and 13.76 ± 8.60, respectively. The patients reported more problems during the pandemic ( P < 0.05) regarding pain/discomfort (odds ratio [OR], 1.78), worrying (OR, 1.89), concerns about persistence/reoccurrence of disease (OR, 1.88), and social relationships (OR, 1.69). The HRQoL outcomes showed strong correlations with each other (range of rs , |0.69| to |0.99|). The Skindex-16, DLQI, and DLQI-R were able to discriminate between severity groups with large (η 2 = 0.20-0.23), whereas the EQ-5D-5L with moderate effect sizes (η 2 = 0.08-0.11). CONCLUSIONS: Atopic dermatitis patients experienced significantly more problems in some areas of HRQoL during the pandemic. The EQ-5D-5L, Skindex-16, DLQI, and DLQI-R demonstrated good convergent and known-group validity and can be suitable instruments for HRQoL assessment in clinical and research settings.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Dermatitis, Atopic / COVID-19 Type of study: Clinical_trials / Observational_studies / Prevalence_studies / Risk_factors_studies Aspects: Patient_preference Limits: Adult / Humans Language: En Journal: Dermatitis Journal subject: DERMATOLOGIA Year: 2022 Document type: Article Country of publication: United States

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Dermatitis, Atopic / COVID-19 Type of study: Clinical_trials / Observational_studies / Prevalence_studies / Risk_factors_studies Aspects: Patient_preference Limits: Adult / Humans Language: En Journal: Dermatitis Journal subject: DERMATOLOGIA Year: 2022 Document type: Article Country of publication: United States