Aza-Quasi-Favorskii Reaction: Construction of Highly Substituted Aziridines through a Concerted Multibond Rearrangement Process.
J Am Chem Soc
; 144(24): 10943-10949, 2022 06 22.
Article
in En
| MEDLINE
| ID: mdl-35674783
ABSTRACT
A new molecular rearrangement, the aza-Quasi-Favorskii rearrangement, has been developed for the construction of highly substituted aziridines. Electron-deficient O-sulfonyl oximes react readily with α,α-disubstituted acetophenone-derived enolates to furnish highly substituted aziridines via this unprecedented domino process. In-depth computational studies reveal an asynchronous yet concerted nitrenoid-type rearrangement pathway.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Aziridines
Language:
En
Journal:
J Am Chem Soc
Year:
2022
Document type:
Article
Affiliation country:
United States