Correlation between the reduction in hippocampal SirT2 expression and depressive-like behaviors and neurological abnormalities in olfactory bulbectomized mice.
Neurosci Res
; 182: 76-80, 2022 Sep.
Article
in En
| MEDLINE
| ID: mdl-35679997
ABSTRACT
Reduced activity of hippocampal silent information regulator protein 2 (SirT2) has been associated with the development of depression caused by disturbances in neuronal and synaptic plasticity. However, changes in the hippocampal SirTs in olfactory bulbectomized (OBX) mice, an animal model of depression, remain unknown. Therefore, this study examined depressive-like behaviors, hippocampal SirTs, synaptic plasticity-associated proteins, and cell proliferation in OBX mice. The OBX mice showed depressive-like behaviors; reduced SirT2, synaptophysin, and PSD95 levels; and reduced cell proliferation in the hippocampus. These data indicate that decreased hippocampal SirT2 may contribute to pathophysiological depression and strongly affect the psychological state.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Olfactory Bulb
/
Sirtuin 2
Limits:
Animals
Language:
En
Journal:
Neurosci Res
Journal subject:
NEUROLOGIA
Year:
2022
Document type:
Article
Affiliation country:
Japan