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Transformation of dolutegravir into an ultra-long-acting parenteral prodrug formulation.
Deodhar, Suyash; Sillman, Brady; Bade, Aditya N; Avedissian, Sean N; Podany, Anthony T; McMillan, JoEllyn M; Gautam, Nagsen; Hanson, Brandon; Dyavar Shetty, Bhagya L; Szlachetka, Adam; Johnston, Morgan; Thurman, Michellie; Munt, Daniel J; Dash, Alekha K; Markovic, Milica; Dahan, Arik; Alnouti, Yazen; Yazdi, Alborz; Kevadiya, Bhavesh D; Byrareddy, Siddappa N; Cohen, Samuel M; Edagwa, Benson; Gendelman, Howard E.
Affiliation
  • Deodhar S; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
  • Sillman B; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
  • Bade AN; Nebraska Nanomedicine Production Plant, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
  • Avedissian SN; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
  • Podany AT; Department of Pharmacy Practice and Science, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
  • McMillan JM; Department of Pharmacy Practice and Science, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
  • Gautam N; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
  • Hanson B; Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
  • Dyavar Shetty BL; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
  • Szlachetka A; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
  • Johnston M; Nebraska Nanomedicine Production Plant, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
  • Thurman M; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
  • Munt DJ; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
  • Dash AK; Department of Pharmacy Sciences, Creighton University, Omaha, NE, 68178, USA.
  • Markovic M; Department of Pharmacy Sciences, Creighton University, Omaha, NE, 68178, USA.
  • Dahan A; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
  • Alnouti Y; Department of Clinical Pharmacology, Ben-Gurion University of the Negev, Beer-Sheva, 84105, Israel.
  • Yazdi A; Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
  • Kevadiya BD; Exavir Therapeutics, Inc., New York, NY, 10012, USA.
  • Byrareddy SN; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
  • Cohen SM; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
  • Edagwa B; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
  • Gendelman HE; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198, USA. benson.edagwa@unmc.edu.
Nat Commun ; 13(1): 3226, 2022 06 09.
Article in En | MEDLINE | ID: mdl-35680875
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prodrugs / HIV Infections / HIV Integrase Inhibitors Limits: Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2022 Document type: Article Affiliation country: United States Country of publication: United kingdom
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prodrugs / HIV Infections / HIV Integrase Inhibitors Limits: Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2022 Document type: Article Affiliation country: United States Country of publication: United kingdom