Nickel-Catalyzed Four-Component Carbonylation of Ethers and Olefins: Direct Access to γ-Oxy Esters and Amides.
Angew Chem Int Ed Engl
; 61(33): e202207970, 2022 Aug 15.
Article
in En
| MEDLINE
| ID: mdl-35694865
ABSTRACT
Multi-component carbonylation of olefins, a reaction that installs both a carbon-carbon(heteroatom) bond and a carbonyl group across the double bond, is an attractive strategy for alkene functionalization. Herein, we developed a novel nickel-catalyzed four-component carbonylation of olefins with ethers under low CO gas pressure. Using alcohols and amines as the reaction partner, diverse γ-oxy-substituted esters and amides were produced in good yields with excellent functional group tolerance. Notably, Naftidrofuryl, a medicine for the treatment of cerebrovascular disease (CVD), can be synthesized by this process straightforwardly.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Angew Chem Int Ed Engl
Year:
2022
Document type:
Article
Affiliation country:
China