Attenuation of methotrexate induced hepatotoxicity by epigallocatechin 3-gallate.

Pradhan, Ayan; Sengupta, Shilpa; Sengupta, Ritika; Chatterjee, Mitali

Pradhan, Ayan; Sengupta, Shilpa; Sengupta, Ritika; Chatterjee, Mitali.

Affiliation

Pradhan A; Department of Pharmacology, Institute of Postgraduate Medical Education and Research (IPGME&R), Kolkata, India.
Sengupta S; Department of Pharmacology, Institute of Postgraduate Medical Education and Research (IPGME&R), Kolkata, India.
Sengupta R; Department of Pharmacology, Institute of Postgraduate Medical Education and Research (IPGME&R), Kolkata, India.
Chatterjee M; Department of Pharmacology, Institute of Postgraduate Medical Education and Research (IPGME&R), Kolkata, India.

Drug Chem Toxicol ; 46(4): 717-725, 2023 Nov.

Article in En | MEDLINE | ID: mdl-35698845

Subject(s)

Catechin; Chemical and Drug Induced Liver Injury; Rats; Animals; Methotrexate/toxicity; Catechin/pharmacology; Rats, Wistar; Rats, Sprague-Dawley; Chemical and Drug Induced Liver Injury/etiology; Chemical and Drug Induced Liver Injury/prevention & control; Chemical and Drug Induced Liver Injury/metabolism; Antioxidants/pharmacology; Antioxidants/metabolism; Oxidative Stress; Liver; Alkaline Phosphatase/metabolism

Key words

Anti-oxidant; epigallocatechin-3-gallate (EGCG); hepatoprotective effect; methotrexate; rheumatoid arthritis; tea

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Catechin / Chemical and Drug Induced Liver Injury Limits: Animals Language: En Journal: Drug Chem Toxicol Year: 2023 Document type: Article Affiliation country: India Country of publication: United States

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