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Dual Inhibition of Vacuolar-ATPase and TMPRSS2 Is Required for Complete Blockade of SARS-CoV-2 Entry into Cells.
Icho, Simoun; Rujas, Edurne; Muthuraman, Krithika; Tam, John; Liang, Huazhu; Landreth, Shelby; Liao, Mingmin; Falzarano, Darryl; Julien, Jean-Philippe; Melnyk, Roman A.
Affiliation
  • Icho S; Molecular Medicine Program, The Hospital for Sick Children Research Institute, Toronto, Ontario, Canada.
  • Rujas E; Department of Biochemistry, University of Torontogrid.17063.33, Toronto, Ontario, Canada.
  • Muthuraman K; Molecular Medicine Program, The Hospital for Sick Children Research Institute, Toronto, Ontario, Canada.
  • Tam J; Pharmacokinetic, Nanotechnology and Gene Therapy Group, Faculty of Pharmacy, University of the Basque Country UPV/EHU, Vitoria, Spain.
  • Liang H; Ikerbasque, Basque Foundation for Science, Bilbao, Spain.
  • Landreth S; Biofisika Institute (CSIC, UPV/EHU), Bilbao, Spain.
  • Liao M; Molecular Medicine Program, The Hospital for Sick Children Research Institute, Toronto, Ontario, Canada.
  • Falzarano D; Department of Biochemistry, University of Torontogrid.17063.33, Toronto, Ontario, Canada.
  • Julien JP; Molecular Medicine Program, The Hospital for Sick Children Research Institute, Toronto, Ontario, Canada.
  • Melnyk RA; Molecular Medicine Program, The Hospital for Sick Children Research Institute, Toronto, Ontario, Canada.
Antimicrob Agents Chemother ; 66(7): e0043922, 2022 07 19.
Article in En | MEDLINE | ID: mdl-35703551
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Vacuolar Proton-Translocating ATPases / COVID-19 Drug Treatment Limits: Humans Language: En Journal: Antimicrob Agents Chemother Year: 2022 Document type: Article Affiliation country: Canada Country of publication: United States
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Vacuolar Proton-Translocating ATPases / COVID-19 Drug Treatment Limits: Humans Language: En Journal: Antimicrob Agents Chemother Year: 2022 Document type: Article Affiliation country: Canada Country of publication: United States