Free Radical Promoted Trifluoromethylthiolation of Alkynes to Access SCF3-Containing Dibenzazepines or Dioxodibenzothiazepines.
J Org Chem
; 87(13): 8773-8781, 2022 07 01.
Article
in En
| MEDLINE
| ID: mdl-35709505
ABSTRACT
Persulfate-promoted radical cascade trifluoromethylthiolation of aryl acetylenes with AgSCF3 provides a simple reaction system for the synthesis of SCF3-substituted dibenzazepines or dioxodibenzothiazepines with good Z/E selectivity. The single-crystal X-ray diffraction data confirms the structures of the final products. A series of scaled-up experiments, further transformations, and radical inhibition experiments were operated in the reaction system.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Dibenzazepines
/
Alkynes
Language:
En
Journal:
J Org Chem
Year:
2022
Document type:
Article