The effect of omega-3 fatty acids on active periodontal therapy: A systematic review and meta-analysis.
J Clin Periodontol
; 49(10): 1024-1037, 2022 10.
Article
in En
| MEDLINE
| ID: mdl-35713248
ABSTRACT
AIM:
"Host modulatory therapy" (HMT) with ω-3 fatty acids aims at reducing inflammation. With HMT as an adjunct, a better result of periodontal therapy is expected. The aim of this systematic review and meta-analysis (MA) was to examine the additional effect of ω-3 fatty acids to non-surgical periodontal therapy (SRP) on the probing pocket depth (PPD) and the clinical attachment level (CAL). MATERIALS ANDMETHODS:
MEDLINE-PubMed and Cochrane-CENTRAL libraries were searched up to January 2021 for randomized controlled trials in patients with chronic periodontitis, treated with SRP/placebo as controls and SRP/ω-3 fatty acids as the test group.RESULTS:
The search identified 173 unique abstracts, and screening resulted in 10 eligible publications. Descriptive analysis showed a significant effect on the PPD and CAL in favour of the groups with ω-3 fatty acids in the majority of comparisons. MA revealed that adjunctive use of ω-3 fatty acids to SRP resulted in 0.39 mm more PPD reduction (95% CI -0.58; -0.21) and 0.41 mm more CAL gain (95% CI -0.63; -0.19) than SRP alone.CONCLUSIONS:
In patients with periodontitis, dietary supplementation with ω-3 fatty acids as an adjunct to SRP is more effective in reducing the PPD and improving the CAL than SRP alone. If SRP is indicated, the use of ω-3 fatty acids can be considered for a moderate extra added effect on PPD reduction and CAL gain. The strength of this recommendation is moderate.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Fatty Acids, Omega-3
/
Chronic Periodontitis
Type of study:
Clinical_trials
/
Guideline
/
Systematic_reviews
Limits:
Humans
Language:
En
Journal:
J Clin Periodontol
Year:
2022
Document type:
Article
Affiliation country:
Netherlands