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Species differences between rats and primates (humans and monkeys) in complex cleavage pathways of DS-8500a characterized by 14C-ADME studies in humans and monkeys after administration of two radiolabeled compounds and in vitro studies.
Makino, Chie; Watanabe, Akiko; Kato, Manabu; Shiozawa, Hideyuki; Takakusa, Hideo; Nakai, Daisuke; Honda, Tomoyo; Watanabe, Nobuaki.
Affiliation
  • Makino C; Drug Metabolism and Pharmacokinetics Research Laboratories, Japan. Electronic address: makino.chie.tg@daiichisankyo.co.jp.
  • Watanabe A; Quantitative Clinical Pharmacology Department, Japan.
  • Kato M; Clinical Development Department III, Japan.
  • Shiozawa H; Drug Metabolism and Pharmacokinetics Research Laboratories, Japan.
  • Takakusa H; Drug Metabolism and Pharmacokinetics Research Laboratories, Japan.
  • Nakai D; Translational Science Department I, Daiichi Sankyo Co., Ltd., 1-2-58, Hiromachi, Shinagawa-ku, Tokyo, 140-8710, Japan.
  • Honda T; Drug Metabolism and Pharmacokinetics Research Laboratories, Japan.
  • Watanabe N; Drug Metabolism and Pharmacokinetics Research Laboratories, Japan.
Drug Metab Pharmacokinet ; 45: 100459, 2022 Aug.
Article in En | MEDLINE | ID: mdl-35716472
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxadiazoles / Benzamides Limits: Animals / Humans Language: En Journal: Drug Metab Pharmacokinet Journal subject: FARMACOLOGIA / METABOLISMO Year: 2022 Document type: Article Country of publication: United kingdom
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxadiazoles / Benzamides Limits: Animals / Humans Language: En Journal: Drug Metab Pharmacokinet Journal subject: FARMACOLOGIA / METABOLISMO Year: 2022 Document type: Article Country of publication: United kingdom