Joint toxicity mechanisms of binary emerging PFAS mixture on algae (Chlorella pyrenoidosa) at environmental concentration.
J Hazard Mater
; 437: 129355, 2022 09 05.
Article
in En
| MEDLINE
| ID: mdl-35716567
ABSTRACT
Since traditional Per- and polyfluoroalkyl substances (PFAS) were banned in 2009 due to their bioaccumulation, persistence and biological toxicity, the emerging PFAS have been widely used as their substitutes and entered the aquatic environment in the form of mixtures. However, the joint toxicity mechanisms of these emerging PFAS mixtures to aquatic organisms remain largely unknown. Then, based on the testing of growth inhibition, cytotoxicity, photosynthesis and oxidative stress, and the toxicity mechanism of PFAS mixture (Perfluorobutane sulfonate and Perfluorobutane sulfonamide) to algae was explored using the Gene set enrichment analysis (GSEA). The results revealed that all three emerging PFAS treatments had a certain growth inhibitory effect on Chlorella pyrenoidosa (C. pyrenoidosa), but the toxicity of PFAS mixture was stronger than that of individual PFAS and showed a significant synergistic effect at environmental concentration. The joint toxicity mechanisms of binary PFAS mixture to C. pyrenoidosa were related to the damage of photosynthetic system, obstruction of ROS metabolism, and inhibition of DNA replication. Our findings are conductive to adding knowledge in understanding the joint toxicity mechanisms and provide a basis for assessing the environmental risk of emerging PFAS.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Water Pollutants, Chemical
/
Chlorella
/
Fluorocarbons
Language:
En
Journal:
J Hazard Mater
Journal subject:
SAUDE AMBIENTAL
Year:
2022
Document type:
Article
Affiliation country:
China