Comparative Bioavailability of a Single Dose of Trametinib (TMT212) Containing 9% vs 11% Dimethyl Sulfoxide in Randomized Healthy Volunteers to Assess Long-Term Storage at Room Temperature.

Tan, Eugene Y; Chiparus, Ovidiu; Choudhury, Somesh; Kim, Christina; Lau, Mike; Ziltener, Christoph; Ilankumaran, Palanichamy

Tan, Eugene Y; Chiparus, Ovidiu; Choudhury, Somesh; Kim, Christina; Lau, Mike; Ziltener, Christoph; Ilankumaran, Palanichamy.

Affiliation

Tan EY; Novartis Pharmaceuticals, East Hanover, New Jersey, USA.
Chiparus O; Novartis Pharmaceuticals, East Hanover, New Jersey, USA.
Choudhury S; Novartis Pharmaceuticals, East Hanover, New Jersey, USA.
Kim C; Novartis Pharmaceuticals, East Hanover, New Jersey, USA.
Lau M; Novartis Pharma AG, Basel, Switzerland.
Ziltener C; Novartis Pharma AG, Basel, Switzerland.
Ilankumaran P; Novartis Pharmaceuticals, East Hanover, New Jersey, USA.

Clin Pharmacol Drug Dev ; 11(10): 1203-1210, 2022 10.

Article in En | MEDLINE | ID: mdl-35736001

Subject(s)

Dimethyl Sulfoxide; Area Under Curve; Biological Availability; Cross-Over Studies; Female; Healthy Volunteers; Humans; Male; Middle Aged; Pyridones; Pyrimidinones; Tablets; Temperature; Therapeutic Equivalency

Key words

TMT212; bioavailability; healthy volunteers; storage; trametinib

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Dimethyl Sulfoxide Type of study: Clinical_trials / Prognostic_studies Limits: Female / Humans / Male / Middle aged Language: En Journal: Clin Pharmacol Drug Dev Year: 2022 Document type: Article Affiliation country: United States Country of publication: United States

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