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Taeanamides A and B, Nonribosomal Lipo-Decapeptides Isolated from an Intertidal-Mudflat-Derived Streptomyces sp.
Cui, Jinsheng; Kim, Eunji; Moon, Dong Hyun; Kim, Tae Ho; Kang, Ilnam; Lim, Yeonjung; Shin, Daniel; Hwang, Sunghoon; Du, Young Eun; Song, Myoung Chong; Bae, Munhyung; Cho, Jang-Cheon; Jang, Jichan; Lee, Sang Kook; Yoon, Yeo Joon; Oh, Dong-Chan.
Affiliation
  • Cui J; Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Korea.
  • Kim E; Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Korea.
  • Moon DH; Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Korea.
  • Kim TH; Molecular Mechanism of Antibiotics, Division of Life Science, Department of Bio & Medical Big Data (BK4 Program), Research Institute of Life Science, Gyeongsang National University, Jinju 52828, Korea.
  • Kang I; Department of Biological Sciences, Inha University, Incheon 22212, Korea.
  • Lim Y; Department of Biological Sciences, Inha University, Incheon 22212, Korea.
  • Shin D; Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Korea.
  • Hwang S; Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Korea.
  • Du YE; Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Korea.
  • Song MC; Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Korea.
  • Bae M; College of Pharmacy, Gachon University, Incheon 21936, Korea.
  • Cho JC; Department of Biological Sciences, Inha University, Incheon 22212, Korea.
  • Jang J; Molecular Mechanism of Antibiotics, Division of Life Science, Department of Bio & Medical Big Data (BK4 Program), Research Institute of Life Science, Gyeongsang National University, Jinju 52828, Korea.
  • Lee SK; Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Korea.
  • Yoon YJ; Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Korea.
  • Oh DC; Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Korea.
Mar Drugs ; 20(6)2022 Jun 16.
Article in En | MEDLINE | ID: mdl-35736203
ABSTRACT
Two new lipo-decapeptides, namely taeanamides A and B (1 and 2), were discovered from the Gram-positive bacterium Streptomyces sp. AMD43, which was isolated from a mudflat sample from Anmyeondo, Korea. The exact molecular masses of 1 and 2 were revealed by high-resolution mass spectrometry, and the planar structures of 1 and 2 were elucidated using NMR spectroscopy. The absolute configurations of 1 and 2 were determined using a combined analysis of 1H-1H coupling constants and ROESY correlations, the advanced Marfey's method, and bioinformatics. The putative nonribosomal peptide synthetase pathway for the taeanamides was identified by analyzing the full genome sequence data of Streptomyces sp. AMD43. We also found that taeanamide A exhibited mild anti-tuberculosis bioactivity, whereas taeanamide B showed significant bioactivity against several cancer cell lines.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Streptomyces Country/Region as subject: Asia Language: En Journal: Mar Drugs Journal subject: BIOLOGIA / FARMACOLOGIA Year: 2022 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Streptomyces Country/Region as subject: Asia Language: En Journal: Mar Drugs Journal subject: BIOLOGIA / FARMACOLOGIA Year: 2022 Document type: Article