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Obesity and Pancreatic Cancer: Recent Progress in Epidemiology, Mechanisms and Bariatric Surgery.
Shinoda, Shuhei; Nakamura, Naohiko; Roach, Brett; Bernlohr, David A; Ikramuddin, Sayeed; Yamamoto, Masato.
Affiliation
  • Shinoda S; Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA.
  • Nakamura N; Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA.
  • Roach B; Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA.
  • Bernlohr DA; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.
  • Ikramuddin S; Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA.
  • Yamamoto M; Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.
Biomedicines ; 10(6)2022 May 31.
Article in En | MEDLINE | ID: mdl-35740306
More than 30% of people in the United States (US) are classified as obese, and over 50% are considered significantly overweight. Importantly, obesity is a risk factor not only for the development of metabolic syndrome but also for many cancers, including pancreatic ductal adenocarcinoma (PDAC). PDAC is the third leading cause of cancer-related death, and 5-year survival of PDAC remains around 9% in the U.S. Obesity is a known risk factor for PDAC. Metabolic control and bariatric surgery, which is an effective treatment for severe obesity and allows massive weight loss, have been shown to reduce the risk of PDAC. It is therefore clear that elucidating the connection between obesity and PDAC is important for the identification of a novel marker and/or intervention point for obesity-related PDAC risk. In this review, we discussed recent progress in obesity-related PDAC in epidemiology, mechanisms, and potential cancer prevention effects of interventions, including bariatric surgery with preclinical and clinical studies.
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Prognostic_studies / Screening_studies Language: En Journal: Biomedicines Year: 2022 Document type: Article Affiliation country: United States Country of publication: Switzerland

Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Prognostic_studies / Screening_studies Language: En Journal: Biomedicines Year: 2022 Document type: Article Affiliation country: United States Country of publication: Switzerland