Hodgkin Lymphoma: Biology and Differential Diagnostic Problem.
Diagnostics (Basel)
; 12(6)2022 Jun 20.
Article
in En
| MEDLINE
| ID: mdl-35741318
ABSTRACT
Hodgkin lymphomas (HLs) are lymphoid neoplasms that are morphologically defined as being composed of dysplastic cells, namely, Hodgkin and Reed-Sternberg cells, in a reactive inflammatory background. The biological nature of HLs has long been unclear; however, our understanding of HL-related genetics and tumor microenvironment interactions is rapidly expanding. For example, cell surface overexpression of programmed cell death 1 ligand 1 (CD274/PD-L1) is now considered a defining feature of an HL subset, and targeting such immune checkpoint molecules is a promising therapeutic option. Still, HLs comprise multiple disease subtypes, and some HL features may overlap with its morphological mimics, posing challenging diagnostic and therapeutic problems. In this review, we summarize the recent advances in understanding the biology of HLs, and discuss approaches to differentiating HL and its mimics.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Type of study:
Diagnostic_studies
Language:
En
Journal:
Diagnostics (Basel)
Year:
2022
Document type:
Article
Affiliation country:
Japan
Publication country:
CH
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SUIZA
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SUÍÇA
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SWITZERLAND