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Comparison of the Relative Sensitivity of Clinical, Endoscopic, and Histologic Remission for Detection of Treatment Efficacy in Ulcerative Colitis Trials.
Sedano, Rocio; Hogan, Malcolm; Zou, Guangyong; Narula, Neeraj; Singh, Siddharth; Ma, Christopher; Feagan, Brian G; Jairath, Vipul.
Affiliation
  • Sedano R; Division of Gastroenterology, Department of Medicine, Western University, London, Ontario, Canada.
  • Hogan M; Alimentiv, Inc., London, Ontario, Canada.
  • Zou G; Alimentiv, Inc., London, Ontario, Canada.
  • Narula N; Alimentiv, Inc., London, Ontario, Canada.
  • Singh S; Division of Gastroenterology, Department of Medicine, Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
  • Ma C; Division of Gastroenterology, University of California San Diego, La Jolla, California, USA.
  • Feagan BG; Alimentiv, Inc., London, Ontario, Canada.
  • Jairath V; Division of Gastroenterology and Hepatology, Department of Medicine, University of Calgary, Calgary, Alberta, Canada.
Inflamm Bowel Dis ; 29(2): 324-327, 2023 02 01.
Article in En | MEDLINE | ID: mdl-35749316
This systemic review and quantitative analysis of placebo-controlled ulcerative colitis (UC) induction trials found higher pooled histologic remission rates compared with clinical and endoscopic remission rates at the same timepoint, and no significant differences in pooled relative risks for these outcomes between treatment groups; supporting the concept that histologic remission is not less sensitive than clinical or endoscopic remission.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colitis, Ulcerative Type of study: Clinical_trials / Diagnostic_studies / Systematic_reviews Limits: Humans Language: En Journal: Inflamm Bowel Dis Journal subject: GASTROENTEROLOGIA Year: 2023 Document type: Article Affiliation country: Canada
Fulltext
Add to My VHL
Print
XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colitis, Ulcerative Type of study: Clinical_trials / Diagnostic_studies / Systematic_reviews Limits: Humans Language: En Journal: Inflamm Bowel Dis Journal subject: GASTROENTEROLOGIA Year: 2023 Document type: Article Affiliation country: Canada